compound 12 [Wattanasin et al.,1997] [Ligand Id: 3130] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1205490 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| squalene synthase in Rat [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| GtoPdb | Inhibitory activity against squalene synthase using rat liver microsomal assay | - | 6.64 | pIC50 | 230 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 3039-3044 |
| GtoPdb | The compound was tested for inhibition of purified rat hepatic squalene synthase in the presence of 1.2 mM NADPH and 1.0 mM inorganic pyrophosphate. In vitro assay. | - | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 3039-3044 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
