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ChEMBL ligand: CHEMBL1072 (Betinex, Bumetanide, Bumex, Burinex, Lixil, RO 10-6338, RO-10-6338, RO-106338, S-95008., S95008.) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Organic anion transporter 1/Solute carrier family 22 member 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes | F | 5.26 | pKi | 5500 | nM | Ki | J Pharmacol Exp Ther (2000) 295: 261-265 [PMID:10991988] |
GPR35 in Human [GtoPdb: 102] [UniProtKB: Q9HC97] | ||||||||
GtoPdb | - | - | 5.54 | pEC50 | - | - | - | Pharmacology (2012) 89: 13-7 [PMID:22236570] |
Kidney-specific Na-K-Cl symporter in Human [GtoPdb: 968] [UniProtKB: Q13621] | ||||||||
GtoPdb | - | - | 6.48 | pIC50 | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2002) 365: 193-9 [PMID:11882915] |
Basolateral Na-K-Cl symporter in Human [GtoPdb: 969] [UniProtKB: P55011] | ||||||||
GtoPdb | - | - | 5.6 | pIC50 | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2002) 365: 193-9 [PMID:11882915] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]