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Kidney-specific Na-K-Cl symporter

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Target not currently curated in GtoImmuPdb

Target id: 968

Nomenclature: Kidney-specific Na-K-Cl symporter

Abbreviated Name: NKCC2

Systematic Nomenclature: SLC12A1

Family: SLC12 family of cation-coupled chloride transporters

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 1099 15q21.1 SLC12A1 solute carrier family 12 member 1
Mouse 12 1095 2 61.23 cM Slc12a1 solute carrier family 12, member 1
Rat 12 1095 3q36 Slc12a1 solute carrier family 12 member 1
Previous and Unofficial Names Click here for help
BSC2 | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 | NKCC2 | Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) | urehr3 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1 | solute carrier family 12 (sodium/potassium/chloride transporter), member 1 | solute carrier family 12
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC12A1 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
Pharos
UniProtKB
Wikipedia
Stoichiometry Click here for help
1 Na+ : 1 K+ : 2 Cl- (in)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
bumetanide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.5 pIC50 2
pIC50 6.5 [2]
piretanide Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pIC50 2
pIC50 6.0 [2]
furosemide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.2 pIC50 2
pIC50 5.2 [2]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Bartter syndrome, antenatal, type 1
Synonyms: Antenatal Bartter syndrome [Orphanet: ORPHA93604]
Bartter disease [Disease Ontology: DOID:445]
Disease Ontology: DOID:445
OMIM: 601678
Orphanet: ORPHA93604
References:  1

References

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1. Adachi M, Asakura Y, Sato Y, Tajima T, Nakajima T, Yamamoto T, Fujieda K. (2007) Novel SLC12A1 (NKCC2) mutations in two families with Bartter syndrome type 1. Endocr J, 54 (6): 1003-7. [PMID:17998760]

2. Hannaert P, Alvarez-Guerra M, Pirot D, Nazaret C, Garay RP. (2002) Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs. Naunyn Schmiedebergs Arch Pharmacol, 365 (3): 193-9. [PMID:11882915]

How to cite this page

SLC12 family of cation-coupled chloride transporters: Kidney-specific Na-K-Cl symporter. Last modified on 18/07/2014. Accessed on 18/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=968.