Kidney-specific Na-K-Cl symporter | SLC12 family of cation-coupled chloride transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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Kidney-specific Na-K-Cl symporter

Target not currently curated in GtoImmuPdb

Target id: 968

Nomenclature: Kidney-specific Na-K-Cl symporter

Abbreviated Name: NKCC2

Systematic Nomenclature: SLC12A1

Family: SLC12 family of cation-coupled chloride transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1099 15q15-q21 SLC12A1 solute carrier family 12 member 1
Mouse - 1095 2 61.23 cM Slc12a1 solute carrier family 12, member 1
Rat - 1095 3q36 Slc12a1 solute carrier family 12 member 1
Previous and Unofficial Names
BSC2 | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 | NKCC2 | Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) | urehr3 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1 | solute carrier family 12 (sodium/potassium/chloride transporter), member 1 | solute carrier family 12
Database Links
Specialist databases
Bioparadigms SLC Tables SLC12A1 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
1 Na+ : 1 K+ : 2 Cl- (in)

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
bumetanide Hs Inhibition 6.5 pIC50 2
pIC50 6.5 [2]
piretanide Hs Inhibition 6.0 pIC50 2
pIC50 6.0 [2]
furosemide Hs Inhibition 5.2 pIC50 2
pIC50 5.2 [2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Bartter syndrome, antenatal, type 1
Synonyms: Antenatal Bartter syndrome [Orphanet: ORPHA93604]
Bartter disease [Disease Ontology: DOID:445]
Disease Ontology: DOID:445
OMIM: 601678
Orphanet: ORPHA93604
References:  1


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1. Adachi M, Asakura Y, Sato Y, Tajima T, Nakajima T, Yamamoto T, Fujieda K. (2007) Novel SLC12A1 (NKCC2) mutations in two families with Bartter syndrome type 1. Endocr. J., 54 (6): 1003-7. [PMID:17998760]

2. Hannaert P, Alvarez-Guerra M, Pirot D, Nazaret C, Garay RP. (2002) Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs. Naunyn Schmiedebergs Arch. Pharmacol., 365 (3): 193-9. [PMID:11882915]

How to cite this page

SLC12 family of cation-coupled chloride transporters: Kidney-specific Na-K-Cl symporter. Last modified on 18/07/2014. Accessed on 12/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,