ChEMBL ligand: CHEMBL284969
A1 adenosine receptor in Pig [ChEMBL: CHEMBL1075029] [UniProtKB: Q4VQ11] There should be some charts here, you may need to enable JavaScript!
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] Adenosine A1 receptor in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190] A1 receptor/Adenosine A1 receptor in Mouse [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612] A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] Adenosine A1 receptor in Guinea pig [ChEMBL: CHEMBL2304404] [UniProtKB: P47745] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] A2A receptor/Adenosine A2a receptor in Mouse [ChEMBL: CHEMBL2115] [GtoPdb: 19] [UniProtKB: Q60613] A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] There should be some charts here, you may need to enable JavaScript!
A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] A3 receptor/Adenosine A3 receptor in Mouse [ChEMBL: CHEMBL1075269] [GtoPdb: 21] [UniProtKB: Q61618] A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 adenosine receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075029] [UniProtKB: Q4VQ11]
ChEMBL	Displacement of [3H]CGS21680 from adenosine A1 receptor in pig striatum membrane	B	6.19	pKi	650	nM	Ki	Bioorg. Med. Chem. (2008) 16: 336-353 [PMID:17933541]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in pig cortical membrane	B	9.52	pKi	0.3	nM	Ki	Bioorg. Med. Chem. (2008) 16: 336-353 [PMID:17933541]
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
GtoPdb	-	-	9.2	pKd	0.63	nM	Kd	J Biol Chem (1999) 274: 3617-21 [PMID:9920910]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]
ChEMBL	Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 mins	B	7.82	pKi	15.3	nM	Ki	J. Med. Chem. (2012) 55: 7719-7735 [PMID:22889387]
ChEMBL	Binding affinity to human adenosine A1 receptor expressed in CHO cells	B	7.82	pKi	15.1	nM	Ki	J. Med. Chem. (2008) 51: 5875-5879 [PMID:18729349]
ChEMBL	Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membranes	B	7.83	pKi	14.9	nM	Ki	J. Med. Chem. (2014) 57: 7673-7686 [PMID:25181013]
ChEMBL	In vitro binding affinity towards human adenosine A1 receptor by [3H]DPCPX displacement.	B	8.19	pKi	6.4	nM	Ki	J. Med. Chem. (2003) 46: 1492-1503 [PMID:12672250]
ChEMBL	Displacement of [3H]-CCPA from human A1 receptor stably expressed in CHO cell membranes by radioligand competitive binding assay	B	8.92	pKi	1.2	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cells	B	9.08	pKi	0.83	nM	Ki	J. Med. Chem. (2005) 48: 8103-8107 [PMID:16366590]
ChEMBL	Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells	B	9.08	pKi	0.83	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 1495-1498 [PMID:15006389]
ChEMBL	Radioligand Binding Assay: Membranes for radioligand binding experiments are prepared from fresh or frozen cells as described in Klotz et al., Naunyn-Schmiedeberg's Arch. Pharmacol, 357:1-9 (1998). The cell suspension is then homogenized in ice-cold hypotonic buffer (5 mM Tris/HCl, 2 mM EDTA, pH 7.4) and the homogenate is spun for 10 minutes (4° C.) at 1,000 g. The membranes are then sedimented from the supernatant for 30 minutes at 100,000 g and resuspended in 50 mM Tris/HCl buffer pH 7.4 (for A3 adenosine receptors: 50 mM Tris/HCl, 10 mM MgCl2, 1 mM EDTA, pH 8.25), frozen in liquid nitrogen at a protein concentration of 1-3 mg/mL and stored at −80° C. Dissociation constants of unlabeled compounds (Ki-values) are determined in competition experiments in 96-well microplates using the A1 selective agonist 2-chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA, 1 nM) for the characterization of A1 receptor binding. Nonspecific binding is determined in the presence of 100 μM R-PM and 1 mM theophylline, respectively.	B	9.08	pKi	0.83	nM	Ki	US-8470800-B2. Method of reducing intraocular pressure in humans (2013)
ChEMBL	Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay	B	9.08	pKi	0.83	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
ChEMBL	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells	B	9.1	pKi	0.8	nM	Ki	Bioorg. Med. Chem. (2008) 16: 336-353 [PMID:17933541]
ChEMBL	Inhibition of cAMP formation in CHO cells expressing adenosine A1 receptor	B	8.89	pIC50	1.3	nM	IC50	J. Med. Chem. (2003) 46: 1492-1503 [PMID:12672250]
ChEMBL	Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis	F	9.3	pIC50	0.5	nM	IC50	J. Med. Chem. (2016) 59: 947-964 [PMID:26756468]
ChEMBL	Agonist activity at human Adenosine A1 receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphai1 after 16 hrs by beta galactosidase reporter gene assay	B	6.7	pEC50	199.53	nM	EC50	J. Med. Chem. (2016) 59: 947-964 [PMID:26756468]
ChEMBL	Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay	F	7.85	pEC50	14	nM	EC50	J. Med. Chem. (2012) 55: 6467-6477 [PMID:22738238]
ChEMBL	Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay	F	8.34	pEC50	4.6	nM	EC50	J. Med. Chem. (2012) 55: 6467-6477 [PMID:22738238]
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL	Displacement of [3H]CGS21680 from adenosine A1 receptor in bovine striatum membrane	B	6.14	pKi	730	nM	Ki	Bioorg. Med. Chem. (2008) 16: 336-353 [PMID:17933541]
ChEMBL	Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovine brain cortical membranes.	B	9.46	pKi	0.35	nM	Ki	J. Med. Chem. (1998) 41: 1708-1715 [PMID:9572897]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in bovine cortical membrane	B	9.47	pKi	0.34	nM	Ki	Bioorg. Med. Chem. (2008) 16: 336-353 [PMID:17933541]
A1 receptor/Adenosine A1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612]
ChEMBL	Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay	B	9.68	pKi	0.21	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
ChEMBL	Agonist activity at mouse adenosine A1 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA	F	7.75	pEC50	17.7	nM	EC50	J. Med. Chem. (2013) 56: 5949-5963 [PMID:23789857]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Affinity towards adenosine A1 receptor from rat cortical membranes using [3H]DPCPX	B	8.02	pKi	9.47	nM	Ki	J. Med. Chem. (2001) 44: 2966-2975 [PMID:11520205]
ChEMBL	Binding affinity for adenosine A1 receptor was assayed by displacement of [3H]DPCPX from rat cortical membranes.	B	8.13	pKi	7.43	nM	Ki	J. Med. Chem. (2000) 43: 250-260 [PMID:10649980]
ChEMBL	Tested for inhibition of adenosine A1 receptor binding to rat brain	B	8.82	pKi	1.5	nM	Ki	Bioorg. Med. Chem. Lett. (1993) 3: 2661-2666
ChEMBL	Displacement of [3H]R-PIA from rat brain membrane Adenosine A1 receptor	B	8.88	pKi	1.33	nM	Ki	J. Med. Chem. (2000) 43: 2196-2203 [PMID:10841798]
ChEMBL	Affinity for adenosine A1 receptor assayed in a competition assay in rat brain using [3H]-CHA as radioligand	B	8.89	pKi	1.3	nM	Ki	J. Med. Chem. (1994) 37: 1720-1726 [PMID:8201607]
ChEMBL	Displacement of [3H]CHA from Adenosine A1 receptor of rat brain	B	8.89	pKi	1.3	nM	Ki	J. Med. Chem. (1995) 38: 3581-3585 [PMID:7658444]
ChEMBL	Binding affinity against adenosine A1 receptor from rat brain using [3H]CHA as a radioligand.	B	8.89	pKi	1.3	nM	Ki	J. Med. Chem. (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL	Inhibition of [3H]- (R)-P1A binding to adenosine A1 receptor	B	9.22	pKi	0.6	nM	Ki	J. Med. Chem. (1991) 34: 3388-3390 [PMID:1766003]
ChEMBL	Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand	B	9.22	pKi	0.6	nM	Ki	J. Med. Chem. (1992) 35: 407-422 [PMID:1738138]
ChEMBL	Tested for the binding affinity of A1 receptor by displacing the [3H]-PIA in rat brain membranes	B	9.22	pKi	0.6	nM	Ki	J. Med. Chem. (1994) 37: 3614-3621 [PMID:7932588]
ChEMBL	Functional activity against adenosine A1 receptor from rat atria.	F	5.09	pEC50	8200	nM	EC50	J. Med. Chem. (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL	Stimulation of [35S]GTP-gamma-S, binding to rat brain membranes by adenosine A1 receptor activation	F	7.52	pEC50	30	nM	EC50	J. Med. Chem. (2000) 43: 250-260 [PMID:10649980]
ChEMBL	Negative chronotropic activity via A1 Adenosine receptor was tested in spontaneously beating rat atria	F	8.09	pEC50	8.2	nM	EC50	J. Med. Chem. (1994) 37: 1720-1726 [PMID:8201607]
ChEMBL	Activity at Adenosine A1 receptor of rat atria	F	8.09	pEC50	8.2	nM	EC50	J. Med. Chem. (1995) 38: 3581-3585 [PMID:7658444]
ChEMBL	Agonist activity at rat A1A adenosine receptor expressed in CHO-K1 cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay	F	8.78	pEC50	1.65	nM	EC50	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
Adenosine A1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304404] [UniProtKB: P47745]
ChEMBL	Ex vivo inhibition of guinea pig ileum twitch via Adenosine A1 receptor.	B	9	pKi	1	nM	Ki	Bioorg. Med. Chem. Lett. (2000) 10: 403-406 [PMID:10714510]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cells	B	5.64	pKi	2300	nM	Ki	Bioorg. Med. Chem. (2008) 16: 336-353 [PMID:17933541]
ChEMBL	Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-5-N-ethylcarboxamidoadenosine from human A2A adenosine receptor expressed in HEK293 cell membranes after 60 mins by scintillation proximity assay	B	5.64	pKi	2270	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
ChEMBL	Displacement of [3H]NECA from human adenosine A2A receptor in stably transfected CHO cells	B	5.64	pKi	2270	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 1495-1498 [PMID:15006389]
ChEMBL	Displacement of [3H]CGS21680 from human A2a adenosine receptor expressed in HEK293 cells after 60 min by Perkin Elmer Liquid Scintillation Analyzer	B	5.64	pKi	2270	nM	Ki	J. Med. Chem. (2012) 55: 8075-8090 [PMID:22921089]
ChEMBL	Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A2A receptor in CHO cells	B	5.64	pKi	2270	nM	Ki	J. Med. Chem. (2005) 48: 8103-8107 [PMID:16366590]
ChEMBL	Displacement of [3H]-NECA from human A2A receptor stably expressed in CHO cell membranes by radioligand competitive binding assay	B	5.69	pKi	2050	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Tested for binding affinity towards human adenosine A2A receptor using [3H]ZM-241385 as radioligand	B	6.19	pKi	639	nM	Ki	J. Med. Chem. (2003) 46: 1492-1503 [PMID:12672250]
ChEMBL	Inhibitory activity at Adenosine A2A receptor by inhibition of [3H]-CGS- 21680 binding to bovine striatal membranes.	B	6.24	pKi	580	nM	Ki	J. Med. Chem. (1998) 41: 1708-1715 [PMID:9572897]
ChEMBL	In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.	B	7.77	pKi	17	nM	Ki	Bioorg. Med. Chem. Lett. (2000) 10: 403-406 [PMID:10714510]
ChEMBL	Agonist activity at human Adenosine A2A receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	B	5	pEC50	10000	nM	EC50	J. Med. Chem. (2016) 59: 947-964 [PMID:26756468]
A2A receptor/Adenosine A2a receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2115] [GtoPdb: 19] [UniProtKB: Q60613]
ChEMBL	Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-5-N-ethylcarboxamidoadenosine from mouse A2A adenosine receptor expressed in HEK293 cell membranes after 60 mins by scintillation proximity assay	B	6.01	pKi	988	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL	Tested for the binding affinity of A2a receptor by displacing the [3H]-CGS- 21680 in rat striatal membranes	B	6.02	pKi	950	nM	Ki	J. Med. Chem. (1994) 37: 3614-3621 [PMID:7932588]
ChEMBL	Binding affinity against adenosine A2a receptor from rat striatum using [3H]-CGS- 21680 as a radioligand.	B	6.19	pKi	650	nM	Ki	J. Med. Chem. (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL	Displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatum	B	6.19	pKi	650	nM	Ki	J. Med. Chem. (1995) 38: 3581-3585 [PMID:7658444]
ChEMBL	Binding affinity for adenosine A2A receptor was determined by displacement of [3H]-DPCPX from rat striatal membranes.	B	6.19	pKi	640	nM	Ki	J. Med. Chem. (2000) 43: 250-260 [PMID:10649980]
ChEMBL	Displacement of specific [3H]-CGS- 21680 binding to adenosine A2A receptor in rat striatal membranes	B	6.22	pKi	605	nM	Ki	J. Med. Chem. (2000) 43: 2196-2203 [PMID:10841798]
ChEMBL	Functional activity at Adenosine A2A receptor as vasorelaxation of rat aorta	F	5	pEC50	>10000	nM	EC50	J. Med. Chem. (1995) 38: 3581-3585 [PMID:7658444]
ChEMBL	Functional activity against adenosine A2a receptor from rat aorta.	F	8	pEC50	>10	nM	EC50	J. Med. Chem. (1995) 38: 1462-1472 [PMID:7739005]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
ChEMBL	Displacement of [3H]- ZM-241385 from human adenosine A2B receptor expressed in HEK cells	B	4.69	pKi	20400	nM	Ki	J. Med. Chem. (2000) 43: 2196-2203 [PMID:10841798]
ChEMBL	Agonist activity at human recombinant adenosine A2B receptor expressed in CHO cells assessed as activation of adenylyl cyclase activity	F	7.38	pKi	42	nM	Ki	Bioorg. Med. Chem. (2008) 16: 336-353 [PMID:17933541]
ChEMBL	Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase reporter gene assay	B	4.14	pEC50	72443.6	nM	EC50	J. Med. Chem. (2016) 59: 947-964 [PMID:26756468]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cells	B	4.73	pKi	18800	nM	Ki	Bioorg. Med. Chem. (2008) 16: 336-353 [PMID:17933541]
ChEMBL	Binding affinity towards Adenosine A3 receptor (H95A mutant receptor)	B	6.1	pKi	796	nM	Ki	J. Med. Chem. (2002) 45: 4471-4484 [PMID:12238926]
ChEMBL	Inhibition of [125 I]-IABMECA binding to human adenosine A3 receptor	B	6.55	pKi	281	nM	Ki	J. Med. Chem. (2003) 46: 1492-1503 [PMID:12672250]
ChEMBL	Affinity towards Adenosine A3 receptor expressed in HEK 293 cells using [125I]AB-MECA radioligand	B	6.69	pKi	204	nM	Ki	J. Med. Chem. (2001) 44: 2966-2975 [PMID:11520205]
ChEMBL	Binding affinity towards human Adenosine A3 receptor wild type	B	6.94	pKi	114	nM	Ki	J. Med. Chem. (2002) 45: 4471-4484 [PMID:12238926]
ChEMBL	Binding affinity towards Adenosine A3 receptor (W243 mutant receptor)	B	7	pKi	100	nM	Ki	J. Med. Chem. (2002) 45: 4471-4484 [PMID:12238926]
ChEMBL	Displacement of [3H]NECA from human adenosine A3 receptor in stably transfected HEK cells	B	7.37	pKi	42.3	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 1495-1498 [PMID:15006389]
ChEMBL	Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from human A3A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay	B	7.42	pKi	38	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
ChEMBL	Bnding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one as radioligand	B	7.42	pKi	38	nM	Ki	J. Med. Chem. (2002) 45: 4471-4484 [PMID:12238926]
ChEMBL	Affinity for human Adenosine A3 receptor expressed in CHO cell	B	7.42	pKi	38	nM	Ki	J. Med. Chem. (2002) 45: 4471-4484 [PMID:12238926]
ChEMBL	Binding affinity to human adenosine A3 receptor in CHO cells	B	7.42	pKi	38	nM	Ki	J. Med. Chem. (2005) 48: 8103-8107 [PMID:16366590]
ChEMBL	Binding affinity to Adenosine receptor A3 (unknown origin)	B	7.42	pKi	38	nM	Ki	J. Med. Chem. (2016) 59: 810-840 [PMID:26390077]
ChEMBL	Binding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor in the presence of GTPgammaS using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one as radioligand	B	7.47	pKi	34	nM	Ki	J. Med. Chem. (2002) 45: 4471-4484 [PMID:12238926]
ChEMBL	Displacement of [3H]-HEMADO from human A3 receptor stably expressed in CHO cell membranes by radioligand competitive binding assay	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by multimode microplate reader analysis	F	7.95	pIC50	11.22	nM	IC50	J. Med. Chem. (2016) 59: 947-964 [PMID:26756468]
A3 receptor/Adenosine A3 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075269] [GtoPdb: 21] [UniProtKB: Q61618]
ChEMBL	Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from mouse A3A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay	B	7.77	pKi	17	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
ChEMBL	Tested for the binding affinity of A3 receptor by displacing N6-[[125I]-4-amino-3-iodobenzyl]-adenosine-5''-N-methyluronamide from membranes of CHO cells transfected with rat A3-cDNA	B	6.63	pKi	237	nM	Ki	J. Med. Chem. (1994) 37: 3614-3621 [PMID:7932588]
ChEMBL	Displacement of [125I]- AB-MECA from rat adenosine A3 receptor expressed in HEK cells	B	6.63	pKi	237	nM	Ki	J. Med. Chem. (2000) 43: 2196-2203 [PMID:10841798]
ChEMBL	Binding affinity to rat adenosine A3 receptor in CHO cells	B	6.63	pKi	237	nM	Ki	J. Med. Chem. (2005) 48: 8103-8107 [PMID:16366590]
ChEMBL	Inhibitory activity against Adenosine A3 receptor by inhibiting specific [3H](R)-PIA binding to rat testis membranes	B	7.52	pKi	30	nM	Ki	J. Med. Chem. (1998) 41: 1708-1715 [PMID:9572897]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]