guanine [Ligand Id: 4556] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL219568 (2-aminohypoxanthine, Ci 75170, C.i. no. 75170 (guanine), Guanine, Valacyclovir hydrochloride, guanine-, Valganciclovir hydrochloride impurity b) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3217379] [UniProtKB: P26281] | ||||||||
| ChEMBL | Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in presence of AMP-CPP | B | 4.42 | pKd | 38000 | nM | Kd | Bioorg Med Chem (2014) 22: 2157-2165 [PMID:24613625] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 | F | 4.22 | pIC50 | 60000 | nM | IC50 | J Med Chem (2006) 49: 7479-7486 [PMID:17149876] |
| ChEMBL | Inhibition of [3H]hypoxanthine uptake in Plasmodium falciparum 3D7 | F | 4.45 | pIC50 | 35300 | nM | IC50 | J Med Chem (2006) 49: 7479-7486 [PMID:17149876] |
| purine nucleoside phosphorylase/Purine nucleoside phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4338] [GtoPdb: 2841] [UniProtKB: P00491] | ||||||||
| ChEMBL | Competitive inhibition of human erythrocyte purine nucleoside phosphorylase assessed as inhibition of guanosine phosphorylysis after 30 mins by Lineweaver-Burk plot analysis | B | 5.3 | pKi | 5000 | nM | Ki | J Med Chem (1978) 21: 877-882 [PMID:31484] |
| ChEMBL | Compound was tested for inhibition of purine nucleoside phosphorylase using human erythro lysate | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (1986) 29: 2034-2037 [PMID:3093681] |
| Purine nucleoside phosphorylase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2935] [UniProtKB: P55859] | ||||||||
| ChEMBL | Binding affinity to calf recombinant PNP Phe159Trp mutant expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis | B | 5.48 | pKd | 3300 | nM | Kd | Bioorg Med Chem (2012) 20: 6758-6769 [PMID:23040896] |
| ChEMBL | Binding affinity to calf recombinant PNP Phe200Trp mutant expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis | B | 6.8 | pKd | 160 | nM | Kd | Bioorg Med Chem (2012) 20: 6758-6769 [PMID:23040896] |
| ChEMBL | Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis | B | 6.8 | pKd | 160 | nM | Kd | Bioorg Med Chem (2012) 20: 6758-6769 [PMID:23040896] |
| ChEMBL | Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry | B | 6.92 | pKd | 120 | nM | Kd | Bioorg Med Chem (2012) 20: 6758-6769 [PMID:23040896] |
| purine nucleoside phosphorylase/Purine-nucleoside phosphorylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2395] [GtoPdb: 2841] [UniProtKB: P85973] | ||||||||
| ChEMBL | Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) | B | 5.3 | pKi | 5000 | nM | Ki | J Med Chem (1994) 37: 2477-2480 [PMID:8057293] |
| Shiga toxin subunit A in Shigella dysenteriae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879822] [UniProtKB: Q9FBI2] | ||||||||
| ChEMBL | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay | B | 4.94 | pIC50 | 11500 | nM | IC50 | J Med Chem (2016) 59: 10763-10773 [PMID:27933947] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
