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ChEMBL ligand: CHEMBL1000 (AC-170, Cetiderm, Cetirizine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG | B | 4.5 | pIC50 | 31622.78 | nM | IC50 | Eur J Med Chem (2011) 46: 618-630 [PMID:21185626] |
ChEMBL | Inhibition of human Potassium channel HERG expressed in mammalian cells | B | 4.52 | pIC50 | 30199.52 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512] |
ChEMBL | Inhibitory concentration against potassium channel HERG | B | 4.52 | pIC50 | 30199.52 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273] |
ChEMBL | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique | B | 4.52 | pIC50 | 30199.52 | nM | IC50 | Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342] |
ChEMBL | Inhibition of human ERG potassium channel in HEK293 cells by patch clamp assay | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5507-5512 [PMID:16931010] |
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] | ||||||||
ChEMBL | Displacement of [3H]mepyramine from human histamine H1 receptor N7.45C mutant expressed in COS-7 cells by liquid scintillation counting | B | 7.1 | pKi | 79.43 | nM | Ki | Nat Chem Biol (2005) 1: 98-103 [PMID:16408006] |
ChEMBL | Displacement of [3H]mepyramine from human histamine H1 receptor N7.45S mutant expressed in COS-7 cells by liquid scintillation counting | B | 7.2 | pKi | 63.1 | nM | Ki | Nat Chem Biol (2005) 1: 98-103 [PMID:16408006] |
ChEMBL | Displacement of [3H]mepyramine from human histamine H1 receptor N7.45Q mutant expressed in COS-7 cells by liquid scintillation counting | B | 7.2 | pKi | 63.1 | nM | Ki | Nat Chem Biol (2005) 1: 98-103 [PMID:16408006] |
ChEMBL | Displacement of [3H]mepyramine from human histamine H1 receptor S3.36A mutant expressed in COS-7 cells by liquid scintillation counting | B | 7.3 | pKi | 50.12 | nM | Ki | Nat Chem Biol (2005) 1: 98-103 [PMID:16408006] |
ChEMBL | Displacement of [3H]mepyramine from human wild-type histamine H1 receptor expressed in COS-7 cells by liquid scintillation counting | B | 7.3 | pKi | 50.12 | nM | Ki | Nat Chem Biol (2005) 1: 98-103 [PMID:16408006] |
ChEMBL | Displacement of [3H]mepyramine from human histamine H1 receptor S3.36C mutant expressed in COS-7 cells by liquid scintillation counting | B | 7.5 | pKi | 31.62 | nM | Ki | Nat Chem Biol (2005) 1: 98-103 [PMID:16408006] |
ChEMBL | Displacement of [3H]mepyramine from human histamine H1 receptor S3.36T mutant expressed in COS-7 cells by liquid scintillation counting | B | 7.5 | pKi | 31.62 | nM | Ki | Nat Chem Biol (2005) 1: 98-103 [PMID:16408006] |
ChEMBL | In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells | B | 7.85 | pKi | 14 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2265-2268 [PMID:15081022] |
ChEMBL | Inhibition constant against histamine H1 receptor | B | 7.85 | pKi | 14 | nM | Ki | J Med Chem (2005) 48: 6523-6543 [PMID:16220969] |
ChEMBL | Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cells | B | 7.85 | pKi | 14 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5591-5594 [PMID:15482930] |
GtoPdb | - | - | 8.2 | pKi | - | - | - | Eur J Biochem (1994) 224: 489-95 [PMID:7925364] |
ChEMBL | Binding affinity for human Histamine H1 receptor in CHO K1 cells | B | 8.23 | pKi | 5.89 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1083-1085 [PMID:15686917] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | DNDI: Malaria in Vitro, 72 hour | F | 4.7 | pIC50 | 19980 | nM | IC50 | Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning |
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] | ||||||||
ChEMBL | Binding affinity to human recombinant Tie2 by SPR assay | B | 4.05 | pKd | 90000 | nM | Kd | Bioorg Med Chem Lett (2012) 22: 2388-2392 [PMID:22406116] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]