ChEMBL ligand: CHEMBL160 (27-400, ANTIBIOTIC S-7481F1, Atopica, Capimune, Capsorin, Cequa, Ciclosporin, Ciclosporin a, Ciclosporinum, Cyclosporin, Cyclosporin a, Cyclosporine, Cyclosporine a, Cyclosporine microemulsion, Cyclosporine, modified, Deximune, Equoral, Gengraf, Ikervis, Mitogard, Neoplanta, Neoral, Neurostat, NSC-290193, OL-27-400, Optimmune, Ramihyphin a, Restasis, Restasis multidose, Sandimmun, Sandimmune, SANG-35, Sangcya, SDZ-OXL-400, Vanquoral, Verkazia, Zinograf me)
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] There should be some charts here, you may need to enable JavaScript!
ABCB11/Bile salt export pump in Human [ChEMBL: CHEMBL6020] [GtoPdb: 778] [UniProtKB: O95342] ABCB11/Bile salt export pump in Rat [ChEMBL: CHEMBL2073674] [GtoPdb: 778] [UniProtKB: O70127] There should be some charts here, you may need to enable JavaScript!
Calcineurin B alpha in Human [ChEMBL: CHEMBL2082] [UniProtKB: P63098] There should be some charts here, you may need to enable JavaScript!
ABCC2/Canalicular multispecific organic anion transporter 1 in Human [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887] ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] There should be some charts here, you may need to enable JavaScript!
ABCC3/Canalicular multispecific organic anion transporter 2 in Human [ChEMBL: CHEMBL5918] [GtoPdb: 781] [UniProtKB: O15438] There should be some charts here, you may need to enable JavaScript!
peptidylprolyl isomerase A/Cyclophilin A in Human [ChEMBL: CHEMBL1949] [GtoPdb: 2751] [UniProtKB: P62937] There should be some charts here, you may need to enable JavaScript!
Cyclophilin B in Human [ChEMBL: CHEMBL2075] [UniProtKB: P23284] There should be some charts here, you may need to enable JavaScript!
CYP3A4/Cytochrome P450 3A4 in Human [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684] There should be some charts here, you may need to enable JavaScript!
dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127] There should be some charts here, you may need to enable JavaScript!
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] There should be some charts here, you may need to enable JavaScript!
FK506-binding protein 1B in Human [ChEMBL: CHEMBL2430] [UniProtKB: P68106] There should be some charts here, you may need to enable JavaScript!
FKBP prolyl isomerase 4/FK506 binding protein 4 in Human [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790] There should be some charts here, you may need to enable JavaScript!
FPR1/Formyl peptide receptor 1 in Human [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547] There should be some charts here, you may need to enable JavaScript!
Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] There should be some charts here, you may need to enable JavaScript!
Interleukin-2 in Mouse [ChEMBL: CHEMBL2466] [UniProtKB: P04351] There should be some charts here, you may need to enable JavaScript!
ABCC1/Multidrug resistance-associated protein 1 in Human [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527] There should be some charts here, you may need to enable JavaScript!
NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] There should be some charts here, you may need to enable JavaScript!
peptidylprolyl isomerase D/Peptidyl-prolyl cis-trans isomerase D in Human [ChEMBL: CHEMBL1697657] [GtoPdb: 3179] [UniProtKB: Q08752] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] P-glycoprotein 1 in Mouse [ChEMBL: CHEMBL3467] [UniProtKB: P06795] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 3 in Mouse [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform in Mouse [ChEMBL: CHEMBL2189158] [GtoPdb: 2156] [UniProtKB: Q9JHG7] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit [ChEMBL: CHEMBL4693] [UniProtKB: P04191] There should be some charts here, you may need to enable JavaScript!
Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform in Human [ChEMBL: CHEMBL4445] [UniProtKB: Q08209] There should be some charts here, you may need to enable JavaScript!
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6] There should be some charts here, you may need to enable JavaScript!
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] There should be some charts here, you may need to enable JavaScript!
OATP1B3 in Human [GtoPdb: 1221] [UniProtKB: Q9NPD5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
GtoPdb	Inhibition of ABCG2-ATPase activity induced by substrate binding.	-	6.3	pKi	500	nM	Ki	Biochem Biophys Res Commun (2001) 285: 111-7 [PMID:11437380]
ChEMBL	TP_TRANSPORTER: inhibition of ATPase in membrane vesicle from BCRP-expressing Sf9 cells	F	6.3	pKi	500	nM	Ki	Biochem. Biophys. Res. Commun. (2001) 285: 111-117 [PMID:11437380]
ChEMBL	Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay	B	4.2	pIC50	63095.73	nM	IC50	Bioorg. Med. Chem. (2008) 16: 8224-8236 [PMID:18678495]
ChEMBL	Inhibition of sulfasalazine-stimulated BCRP ATP ase activity (unknown origin)	B	5.18	pIC50	>6568	nM	IC50	J Med Chem (2021) 64: 3677-3693 [PMID:33729781]
ChEMBL	Inhibition of BCRP (unknown origin) transfected in HEK293/R2 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assay	B	5.76	pEC50	1750	nM	EC50	J Med Chem (2019) 62: 8578-8608 [PMID:31465686]
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
GtoPdb	-	-	5.12	pKi	7600	nM	Ki	Mol Pharm (2013) 10: 1008-19 [PMID:23339484]
GtoPdb	-	-	6	pIC50	1000	nM	IC50	J Pharmacol Exp Ther (1999) 291: 1204-9 [PMID:10565843]
ChEMBL	TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells	F	6	pIC50	1000	nM	IC50	J. Pharmacol. Exp. Ther. (1999) 291: 1204-1209 [PMID:10565843]
ABCB11/Bile salt export pump in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6020] [GtoPdb: 778] [UniProtKB: O95342]
ChEMBL	TP_TRANSPORTER: inhibition of Taurochenodeoxycholate uptake(CsA 30uM, 30 % of control) in membrane vesicles prepared from High Five cells infected with the ABCB11 baculovirus	F	5.02	pKi	9500	nM	Ki	Gastroenterology (2002) 123: 1649-1658 [PMID:12404239]
ChEMBL	TP_TRANSPORTER: increase in dihydrofluorescein intracellular accumulation (dihydrofluorescein: 1 uM) in SK-E2 cells (expressing BSEP)	F	5.11	pIC50	7800	nM	IC50	Pharm. Res. (2003) 20: 537-544 [PMID:12739759]
ChEMBL	TP_TRANSPORTER: increase in bodipy intracellular accumulation (Bodipy: 0.2 uM) in SK-E2 cells (expressing BSEP)	F	5.12	pIC50	7500	nM	IC50	Pharm. Res. (2003) 20: 537-544 [PMID:12739759]
ChEMBL	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	B	6.3	pIC50	500	nM	IC50	Drug Metab. Dispos. (2012) 40: 130-138 [PMID:21965623]
ABCB11/Bile salt export pump in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073674] [GtoPdb: 778] [UniProtKB: O70127]
ChEMBL	TP_TRANSPORTER: inhibition of Taurocholate uptake in membrane vesicles from Bsep-expressing Sf9 cells	F	6.52	pKi	300	nM	Ki	Gastroenterology (2000) 118: 422-430 [PMID:10648470]
ChEMBL	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	B	6.22	pIC50	600	nM	IC50	Drug Metab. Dispos. (2012) 40: 130-138 [PMID:21965623]
Calcineurin B alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2082] [UniProtKB: P63098]
ChEMBL	Inhibition of CNB (unknown origin) using p-NPP as substrate preincubated for 10 mins followed by substrate addition by spectrophotometry analysis	B	4.47	pIC50	34000	nM	IC50	J Nat Prod (2021) 84: 1579-1586 [PMID:33973788]
ABCC2/Canalicular multispecific organic anion transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
ChEMBL	TP_TRANSPORTER: inhibition of BMG uptake in membrane vesicles from MRP2-expressing HEK cells	F	4.68	pKi	21000	nM	Ki	Hepatology (1999) 30: 485-490 [PMID:10421658]
ChEMBL	TP_TRANSPORTER: inhibition of Vinblastine transepithelial transport (basal to apical) in MRP2-expressing MDCK cells	F	5.09	pKi	8110	nM	Ki	Pharm. Res. (2002) 19: 773-779 [PMID:12134946]
ChEMBL	TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cells	F	5.33	pKi	4700	nM	Ki	Mol. Pharmacol. (1999) 56: 1219-1228 [PMID:10570049]
ChEMBL	Inhibition of ABCC2 (unknown origin) expressed in MDCK2 cells assessed as inhibition of calcein-AM efflux measured after 30 mins in presence of ABCB1 inhibitor GF120918 and ABCC1 inhibitor MK-571 by flow cytometry	B	4.59	pIC50	25600	nM	IC50	Eur J Med Chem (2016) 122: 408-418 [PMID:27393949]
ChEMBL	Inhibition of ABCC2 (unknown origin)	B	4.7	pIC50	20000	nM	IC50	Eur J Med Chem (2016) 122: 408-418 [PMID:27393949]
ChEMBL	Inhibition of sulfasalazine-stimulated MRP2 ATPase activity (unknown origin) in presence of GSH	B	4.79	pIC50	16270	nM	IC50	J Med Chem (2021) 64: 3677-3693 [PMID:33729781]
ChEMBL	Inhibition of human MRP2 expressed in dog MDCK2 cells	B	4.87	pIC50	13600	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 4761-4763 [PMID:18707884]
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL	TP_TRANSPORTER: inhibition of BMG uptake in membrane vesicles from Mrp2-expressing HEK cells	F	5	pKi	10000	nM	Ki	Hepatology (1999) 30: 485-490 [PMID:10421658]
ChEMBL	TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat	F	5.71	pKi	1960	nM	Ki	Drug Metabol. Pharmacokin. (2002) 17: 23-33 [PMID:15618649]
ABCC3/Canalicular multispecific organic anion transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5918] [GtoPdb: 781] [UniProtKB: O15438]
ChEMBL	Inhibition of benzmarone-stimulated MRP3 ATPase activity (unknown origin) in presence of GSH	B	6.2	pIC50	631.5	nM	IC50	J Med Chem (2021) 64: 3677-3693 [PMID:33729781]
peptidylprolyl isomerase A/Cyclophilin A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1949] [GtoPdb: 2751] [UniProtKB: P62937]
ChEMBL	Binding affinity to Cyclophilin A	B	5.19	pKd	6420	nM	Kd	Eur. J. Med. Chem. (2011) 46: 1701-1705 [PMID:21396746]
ChEMBL	Binding affinity towards cyclophilin A by fluorescence	B	6.52	pKd	300	nM	Kd	J. Med. Chem. (2001) 44: 2593-2600 [PMID:11472213]
ChEMBL	Binding affinity to human Cyclophilin A	B	7.43	pKd	36.8	nM	Kd	Bioorg. Med. Chem. Lett. (2008) 18: 3995-3998 [PMID:18571405]
ChEMBL	Inhibition of Cy5-labeled cyclosporin A binding to full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) after 30 mins by TR-FRET assay	B	7.77	pKd	17	nM	Kd	J Med Chem (2018) 61: 9473-9499 [PMID:30074795]
ChEMBL	Inhibition of Cy5-labeled cyclosporin A binding to full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) after 2 hrs by TR-FRET assay	B	7.77	pKd	17	nM	Kd	J Med Chem (2017) 60: 1000-1017 [PMID:28075591]
ChEMBL	Competitive binding affinity to biotinylated human recombinant T cell cyclophilin A expressed in Escherichia coli by spectrophotometric analysis	B	8	pKd	10	nM	Kd	ACS Med. Chem. Lett. (2011) 2: 485-487 [PMID:24900335]
ChEMBL	Binding affinity to cyclophilin A by surface plasmon resonance analysis	B	8	pKd	10	nM	Kd	ACS Med. Chem. Lett. (2011) 2: 485-487 [PMID:24900335]
ChEMBL	Binding affinity to human cyclophilin A by fluorescence polarization assay	B	8	pKd	10	nM	Kd	ACS Med. Chem. Lett. (2011) 2: 485-487 [PMID:24900335]
ChEMBL	Inhibition of fluorescent cyclosporin A binding to human CypA by TR-FRET assay	B	8	pKd	10	nM	Kd	Bioorg Med Chem Lett (2016) 26: 5304-5307 [PMID:27687672]
ChEMBL	Binding affinity to human cyclophilin 18 assessed as reduction in calcineurin activity	B	8.05	pKd	9	nM	Kd	Nat. Chem. Biol. (2009) 5: 724-726 [PMID:19734911]
ChEMBL	Binding affinity to human recombinant cyclophilin-A by isothermal titration calorimetry assay	B	8.12	pKd	7.6	nM	Kd	Eur. J. Med. Chem. (2011) 46: 5556-5561 [PMID:21963115]
ChEMBL	Inhibition of fluorescein labeled cyclosporin binding to Cyp18 by fluorescence polarization competition assay	B	6.64	pKi	231	nM	Ki	ACS Med. Chem. Lett. (2010) 1: 536-539 [PMID:24900244]
ChEMBL	Inhibition of Cyclophilin 18 PPIase activity	B	6.64	pKi	227	nM	Ki	ACS Med. Chem. Lett. (2010) 1: 536-539 [PMID:24900244]
ChEMBL	Inhibition of cyclophilin A rotamase	B	7.7	pKi	20	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 4549-4551 [PMID:15357990]
GtoPdb	-	-	7.76	pKi	17.2	nM	Ki	J Pharmacol Exp Ther (2019) 371: 231-241 [PMID:31406003]
ChEMBL	Inhibition of CypA PPIase activity (unknown origin) using Glt-(Ala)n-Pro-Phe-4-nitroanilides as substrate	B	7.91	pKi	12.2	nM	Ki	J. Med. Chem. (2013) 56: 7302-7311 [PMID:23964991]
ChEMBL	Inhibition of human recombinant cyclophilin-associted cis-trans propyl isomerase activity	B	8.01	pKi	9.79	nM	Ki	Antimicrob. Agents Chemother. (2008) 52: 1302-1317 [PMID:18212100]
ChEMBL	Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Suc-Ala-Ala-Pro-Phe-para-nitroanilide as substrate after 5 mins by spectrophotometric method	B	8.17	pKi	6.7	nM	Ki	J Med Chem (2017) 60: 1000-1017 [PMID:28075591]
ChEMBL	Inhibition of calcineurin phosphatase activity of CyPA	B	8.58	pKi	2.64	nM	Ki	Antimicrob. Agents Chemother. (2010) 54: 660-672 [PMID:19933795]
ChEMBL	Inhibition of recombinant GST-tagged CypA (unknown origin)/HCV Con1 NS5A-His interaction after 16 hrs by ELISA	B	6.02	pIC50	950	nM	IC50	MedChemComm (2012) 3: 944-949
ChEMBL	Binding affinity to human cyclophilin 18	B	7	pIC50	100	nM	IC50	Nat. Chem. Biol. (2009) 5: 724-726 [PMID:19734911]
ChEMBL	In vitro binding affinity against cyclophilin A by ELISA	B	7.21	pIC50	62	nM	IC50	J. Med. Chem. (1995) 38: 3361-3367 [PMID:7650689]
ChEMBL	Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A	B	7.39	pIC50	40.7	nM	IC50	J. Med. Chem. (2009) 52: 5295-5298 [PMID:19691347]
ChEMBL	In vitro binding affinity against cyclophilin A by rotamase assay	B	7.57	pIC50	27	nM	IC50	J. Med. Chem. (1995) 38: 3361-3367 [PMID:7650689]
ChEMBL	Inhibition of CypA (unknown origin) assessed as peptidyl-prolyl cis-trans isomerase activity using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate by spectrophotometry	B	7.64	pIC50	23	nM	IC50	Bioorg. Med. Chem. Lett. (2015) 25: 5682-5686 [PMID:26564266]
ChEMBL	Inhibition of PPIase activity of Cyclophilin A by Spectrophotometry	B	7.99	pIC50	10.25	nM	IC50	Eur. J. Med. Chem. (2011) 46: 1701-1705 [PMID:21396746]
ChEMBL	Inhibition of PPIase activity of recombinant CypA (unknown origin) assessed as chymotrypsin-mediated N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide hydrolysis after 1 hr by spectrophotometric analysis	B	8.02	pIC50	9.6	nM	IC50	MedChemComm (2012) 3: 944-949
ChEMBL	Inhibition of PPIase activity of human recombinant cyclophilin-A using succinyl-Ala-Ala-Pro-Phe-4-nitroanilide as substrate by protease coupled assay	B	8.03	pIC50	9.3	nM	IC50	Eur. J. Med. Chem. (2011) 46: 5556-5561 [PMID:21963115]
ChEMBL	Compound was evaluated for in vitro binding affinity to cyclophilin A (CyP-A)	B	8.05	pIC50	9	nM	IC50	J. Med. Chem. (1994) 37: 3674-3676 [PMID:7966126]
ChEMBL	Binding affinity to cyclophilin A by ELISA	B	8.08	pIC50	8.33	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 6542-6546 [PMID:20943390]
ChEMBL	Inhibition of Cyclophilin A peptidyl-prolyl cis-trans isomerase activity (unknown origin) using Succ-Ala-Leu-Pro-Phe-p-nitroaniline as substrate by ITC analysis	B	8.14	pIC50	7.2	nM	IC50	J. Med. Chem. (2015) 58: 9546-9561 [PMID:26613291]
GtoPdb	-	-	8.3	pIC50	5	nM	IC50	Proc Natl Acad Sci USA (1992) 89: 3686-90 [PMID:1373887]
ChEMBL	Inhibition of PPIase activity of cyclophilin 18 by protease coupled assay	B	8.43	pIC50	3.7	nM	IC50	Nat. Chem. Biol. (2009) 5: 724-726 [PMID:19734911]
ChEMBL	Immunosuppressive activity was measured by inhibition of the IL-2 production in Jurkat cells.	F	8.7	pIC50	2	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 4415-4419 [PMID:14643337]
Cyclophilin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2075] [UniProtKB: P23284]
ChEMBL	Binding affinity to human Cyclophilin B	B	8.01	pKd	9.8	nM	Kd	Bioorg. Med. Chem. Lett. (2008) 18: 3995-3998 [PMID:18571405]
ChEMBL	Binding affinity to cyclophilin B by ELISA	B	8.06	pIC50	8.78	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 6542-6546 [PMID:20943390]
CYP3A4/Cytochrome P450 3A4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684]
ChEMBL	null: A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. CYP3A4A is thought to be one of the primary CYP isoforms responsible for retinoic acid metabolism in the skin. Three benchmark agents, liarozole, climbazole, and ketoconazole, were assessed for CYP3A4 inhibition to confirm that the inhibition activity (the IC50 for CYP3A4 inhibition) measured by the assay corresponds to the activity reported by the published literature. The results show that the substituted azole compounds having the specific structure set forth herein are CYP inhibitors, and thus function as RAMBAs.	B	5	pIC50	>10000	nM	IC50	US-9138393-B2. Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin (2015)
dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127]
ChEMBL	In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH)	B	4.3	pIC50	>50000	nM	IC50	J. Med. Chem. (1998) 41: 3530-3538 [PMID:9719606]
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942]
ChEMBL	Compound was tested for its ability to inhibit FK506 binding protein 12 rotamase activity	B	7.7	pKi	20	nM	Ki	J. Med. Chem. (1998) 41: 5119-5143 [PMID:9857082]
FK506-binding protein 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2430] [UniProtKB: P68106]
ChEMBL	The compound was tested for inhibition of Peptidyl-propyl isomerase (PPIase).	B	8.22	pKi	6	nM	Ki	J. Med. Chem. (1995) 38: 4164-4170 [PMID:7473543]
FKBP prolyl isomerase 4/FK506 binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790]
ChEMBL	50% inhibitory concentration of competitive binding against hCyp-18 PPIase activity using uncoupled assay	B	7.8	pIC50	16	nM	IC50	J. Med. Chem. (2000) 43: 1770-1779 [PMID:10794694]
FPR1/Formyl peptide receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462]
ChEMBL	Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells	B	5	pIC50	>10000	nM	IC50	J. Med. Chem. (2002) 45: 4613-4628 [PMID:12361388]
GtoPdb	-	-	6.3	pEC50	-	-	-	Biochem Pharmacol (1997) 54: 695-701 [PMID:9310346]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL	In vitro inhibitory activity against HIV-1 RT in CEM4 cell line	B	6.34	pIC50	455	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 4415-4419 [PMID:14643337]
Sodium/bile acid and sulphated solute cotransporter 2/Ileal bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908]
ChEMBL	TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells	F