glutathione [Ligand Id: 6737] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1543 (Glutathione)
  • Glutathione S-transferase kappa 1 in Human [ChEMBL: CHEMBL4491] [UniProtKB: Q9Y2Q3]
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  • euchromatic histone lysine methyltransferase 2/Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 in Human [ChEMBL: CHEMBL6032] [GtoPdb: 2652] [UniProtKB: Q96KQ7]
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  • euchromatic histone lysine methyltransferase 1/Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 in Human [ChEMBL: CHEMBL6031] [GtoPdb: 2651] [UniProtKB: Q9H9B1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Glutathione S-transferase kappa 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4491] [UniProtKB: Q9Y2Q3]
ChEMBL Affinity towards recombinant Glutathione S-transferase (GST) Enzyme. B 7.7 pIC50 20 nM IC50 J. Med. Chem. (1998) 41: 2278-2288 [PMID:9632361]
euchromatic histone lysine methyltransferase 2/Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6032] [GtoPdb: 2652] [UniProtKB: Q96KQ7]
ChEMBL Inhibition of wild type recombinant human histone lysine methyltransferase G9a (913 to 1193 residues) expressed in Escherichia coli Rosetta BL21 DE3 PlysS using ARTKQTARKSTGGKA as substrate preincubated for 5 mins followed by substrate/SAM addition measured after 60 mins by MALDI-TOF MS analysis B 4 pIC50 >100000 nM IC50 Bioorg Med Chem Lett (2018) 28: 1234-1238 [PMID:29519735]
euchromatic histone lysine methyltransferase 1/Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6031] [GtoPdb: 2651] [UniProtKB: Q9H9B1]
ChEMBL Inhibition of wild type recombinant human histone lysine methyltransferase GLP (951 to 1235 residues) expressed in Escherichia coli Rosetta BL21 DE3 PlysS using ARTKQTARKSTGGKA as substrate preincubated for 5 mins followed by substrate/SAM addition measured after 60 mins by MALDI-TOF MS analysis B 4 pIC50 >100000 nM IC50 Bioorg Med Chem Lett (2018) 28: 1234-1238 [PMID:29519735]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]