Synonyms: ASP-1517 | ASP1517 | Evrenzo® | FG-4592 | FG4592
roxadustat is an approved drug (EMA (2021))
Compound class:
Synthetic organic
Comment: Roxadustat is a compound which inhibits hypoxia inducible factor prolyl hydroxylase (HIF-PH) activity. HIF-PH inhibitors are being investigated as novel therapies for anemia, especially anemia caused by chronic kindney disease (CKD) [2]. It is hoped that HIF-PH inhibitors will provide a more effective alternative to the use of erythropoetin replacement therapy plus iron supplementation in CKD patients.
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes (EMA (2021)) |
Approved drug? | Yes. EMA (2021) |
IUPAC Name ![]() |
2-[[4-hydroxy-1-methyl-7-(phenoxy)isoquinoline-3-carbonyl]amino]acetic acid |
International Nonproprietary Names ![]() |
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INN number | INN |
9717 | roxadustat |
Synonyms ![]() |
ASP-1517 | ASP1517 | Evrenzo® | FG-4592 | FG4592 |
Database Links ![]() |
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CAS Registry No. | 808118-40-3 |
ChEMBL Ligand | CHEMBL2338329 |
DrugCentral Ligand | 5371 |
GtoPdb PubChem SID | 252166664 |
PubChem CID | 11256664 |
RCSB PDB Ligand | 8HO |
Search Google for chemical match using the InChIKey | YOZBGTLTNGAVFU-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | YOZBGTLTNGAVFU |
Search PubMed clinical trials | roxadustat |
Search PubMed titles | roxadustat |
Search PubMed titles/abstracts | roxadustat |
UniChem Compound Search for chemical match using the InChIKey | YOZBGTLTNGAVFU-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | YOZBGTLTNGAVFU-UHFFFAOYSA-N |