dipraglurant [Ligand Id: 6452] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2346738 (Adx48621, ADX48621, ADX-48621, Dipraglurant)
  • mGlu5 receptor/Metabotropic glutamate receptor 5 in Human [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
ChEMBL Negative allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay F 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 2134-2139 [PMID:23434029]
GtoPdb - - 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2013) 23: 2134-9 [PMID:23434029]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]