ChEMBL ligand: CHEMBL1708510 (CID 27456)
GPR35/G-protein coupled receptor 35 in Human [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
GtoPdb	In a competition radiologand binding assay membranes preapred from CHO cells recombinantly expressing human GPR35.	-	7.37	pKi	42.2	nM	Ki	J Med Chem (2013) 56: 7084-99 [PMID:23888932]
ChEMBL	Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis	B	7.37	pKi	42.2	nM	Ki	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
GtoPdb	Antagonism of the GPR35 response to 1 μM pamoic acid in a βarrestin2-GFP trafficking assay.	-	7.89	pKi	12.8	nM	Ki	Mol Pharmacol (2010) 78: 560-8 [PMID:20826425]
GtoPdb	Antagonism of zaprinast-mediated activation of GPR35 in a dynamic mass redistribution assay.	-	4.98	pIC50	10400	nM	IC50	J Med Chem (2013) 56: 7084-99 [PMID:23888932]
ChEMBL	Antagonist activity at human GPR35 expressed in human HT29 cells after 1 hr by DMR assay	B	4.98	pIC50	10400	nM	IC50	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL	Antagonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay	B	6.24	pIC50	574	nM	IC50	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL	Antagonist activity at human Gal4-VP16 fused GPR35 expressed in human U2OS cells assessed as beta arrestin translocation by reporter gene assay	B	6.7	pIC50	200	nM	IC50	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
GtoPdb	Antagonism of zaprinast-mediated activation of GPR35 in a β-arrestin assay.	-	6.7	pIC50	200	nM	IC50	J Med Chem (2013) 56: 7084-99 [PMID:23888932]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]