ChEMBL ligand: CHEMBL1708510
GPR35 in Human [GtoPdb: 102] [UniProtKB: Q9HC97] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GPR35 in Human [GtoPdb: 102] [UniProtKB: Q9HC97]
GtoPdb	In a competition radiologand binding assay membranes preapred from CHO cells recombinantly expressing human GPR35.	-	7.37	pKi	42.2	nM	Ki	J Med Chem (2013) 56: 7084-99 [PMID:23888932]
GtoPdb	Antagonism of the GPR35 response to 1 μM pamoic acid in a βarrestin2-GFP trafficking assay.	-	7.89	pKi	12.8	nM	Ki	Mol Pharmacol (2010) 78: 560-8 [PMID:20826425]
GtoPdb	Antagonism of zaprinast-mediated activation of GPR35 in a dynamic mass redistribution assay.	-	4.98	pIC50	10400	nM	IC50	J Med Chem (2013) 56: 7084-99 [PMID:23888932]
GtoPdb	Antagonism of zaprinast-mediated activation of GPR35 in a β-arrestin assay.	-	6.7	pIC50	200	nM	IC50	J Med Chem (2013) 56: 7084-99 [PMID:23888932]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]