ChEMBL ligand: CHEMBL363559 (dTTP)
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL	Inhibition of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase M184V mutant assessed as incorporation of dTMP by burst assay using DNA/DNA Primer/Template combination	B	4.14	pKd	73200	nM	Kd	Antimicrob Agents Chemother (2008) 52: 2035-2042 [PMID:18391035]
ChEMBL	Inhibition of RNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of dTMP by burst assay using RNA/DNA Primer/Template combination	B	4.17	pKd	67100	nM	Kd	Antimicrob Agents Chemother (2008) 52: 2035-2042 [PMID:18391035]
ChEMBL	Inhibition of DNA-dependent DNA polymerase activity of HIV 1 reverse transcriptase assessed as incorporation of dTMP by burst assay using DNA/DNA Primer/Template combination	B	4.81	pKd	15400	nM	Kd	Antimicrob Agents Chemother (2008) 52: 2035-2042 [PMID:18391035]
ChEMBL	Binding affinity to HIV1 LAI reverse transcriptase M184V mutant	B	5.55	pKd	2850	nM	Kd	Antimicrob Agents Chemother (2008) 52: 157-163 [PMID:17967907]
ChEMBL	Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant	B	5.58	pKd	2650	nM	Kd	Antimicrob Agents Chemother (2008) 52: 157-163 [PMID:17967907]
ChEMBL	Binding affinity to HIV1 reverse transcriptase	B	5.66	pKd	2200	nM	Kd	Antimicrob Agents Chemother (2009) 53: 3715-3719 [PMID:19596885]
ChEMBL	Binding affinity to wild type HIV1 LAI reverse transcriptase	B	5.68	pKd	2080	nM	Kd	Antimicrob Agents Chemother (2008) 52: 157-163 [PMID:17967907]
ChEMBL	Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutant	B	5.92	pKd	1200	nM	Kd	Antimicrob Agents Chemother (2008) 52: 157-163 [PMID:17967907]
ChEMBL	Inhibitory constant against HIV-1 reverse transcriptase	B	7.21	pKi	61	nM	Ki	J Med Chem (2005) 48: 2695-2700 [PMID:15801860]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]