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doripenem   Click here for help

GtoPdb Ligand ID: 12183

Synonyms: compound 1m [PMID: 8621362] | Doribax® | S-4661
Approved drug PDB Ligand
doripenem is an approved drug (FDA (2007))
Compound class: Synthetic organic
Comment: Doripenem is a parenterally delivered, carbapenem antibacterial compound. It is a semi-synthetic derivative of thienamycin and was developed by the Shionogi Research Laboratories (Osaka, Japan) [1].

doripenem is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 5
Rotatable bonds 7
Topological polar surface area 195.74
Molecular weight 420.11
XLogP -4.18
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C[C@H]([C@H]1C(=O)N2[C@@H]1[C@@H](C)C(=C2C(=O)O)S[C@@H]1CN[C@@H](C1)CNS(=O)(=O)N)O
Isomeric SMILES C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]1C[C@H](NC1)CNS(=O)(=O)N)C(=O)O)[C@@H](C)O
InChI InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1
InChI Key AVAACINZEOAHHE-VFZPANTDSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (2007)
IUPAC Name Click here for help
(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
7975 doripenem
Synonyms Click here for help
compound 1m [PMID: 8621362] | Doribax® | S-4661
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Doripenem
Other databases
CAS Registry No. 148016-81-3 (source: Scifinder)
ChEBI CHEBI:135928
ChEMBL Ligand CHEMBL491571
DrugBank Ligand DB06211
DrugCentral Ligand 4149
GtoPdb PubChem SID 472319305
PubChem CID 73303
RCSB PDB Ligand O6P
Search Google for chemical match using the InChIKey AVAACINZEOAHHE-VFZPANTDSA-N
Search Google for chemicals with the same backbone AVAACINZEOAHHE
Search PubMed clinical trials doripenem
Search PubMed titles doripenem
Search PubMed titles/abstracts doripenem
UniChem Compound Search for chemical match using the InChIKey AVAACINZEOAHHE-VFZPANTDSA-N
UniChem Connectivity Search for chemical match using the InChIKey AVAACINZEOAHHE-VFZPANTDSA-N
Wikipedia Doripenem

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

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MedChemExpress
Doripenem (links to external site)
Cat. No. HY-B0187