Abbreviated name: DCA
Synonyms: dichloroacetic acid
Compound class:
Synthetic organic
Comment: Dichloroacetate (DCA) is an orally available small molecule pyruvate dehydrogenase kinase inhibitor [4]. It acts as a metabolic regulator and has anti-cancer potential by promoting glucose oxidation over glycolysis, glycolysis being the metabolic pathway (Warburg effect) utilised by most cancer cells to resist apoptosis and gain proliferative advantage [1-3].
ChEMBL represents this compound without the charge (see link above). |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
2,2-dichloroacetate |
Synonyms ![]() |
dichloroacetic acid |
Database Links ![]() |
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Specialist databases | |
Reactome Drug
![]() |
R-ALL-9010792 |
Reactome Reaction
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R-HSA-9011543, R-HSA-9011595 |
Other databases | |
CAS Registry No. | 13425-80-4 (source: Scifinder) |
ChEMBL Ligand | CHEMBL13960 |
GtoPdb PubChem SID | 178101243 |
PubChem CID | 25975 |
Search Google for chemical match using the InChIKey | JXTHNDFMNIQAHM-UHFFFAOYSA-M |
Search Google for chemicals with the same backbone | JXTHNDFMNIQAHM |
UniChem Compound Search for chemical match using the InChIKey | JXTHNDFMNIQAHM-UHFFFAOYSA-M |
UniChem Connectivity Search for chemical match using the InChIKey | JXTHNDFMNIQAHM-UHFFFAOYSA-M |
Wikipedia | Dichloroacetate |