(R)-cetirizine   

GtoPdb Ligand ID: 1214

Synonyms: Vozet® | Xyzal®
(R)-cetirizine is an approved drug (FDA (2007))
Compound class: Synthetic organic
Comment: Levocetirizine is an antihistamine, and is a component of the approved drug cetirizine, but this enantiomer is approved in its own right.
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 53.01
Molecular weight 388.16
XLogP 2.81
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1
Isomeric SMILES OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1
InChI InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)/t21-/m1/s1
InChI Key ZKLPARSLTMPFCP-OAQYLSRUSA-N
Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2007))
IUPAC Name
2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
International Nonproprietary Names
INN number INN
7700 levocetirizine
Synonyms
Vozet® | Xyzal®
Database Links
CAS Registry No. 130018-77-8
ChEMBL Ligand CHEMBL1201191
DrugCentral Ligand 1566
GtoPdb PubChem SID 135650416
PubChem CID 1549000
RCSB PDB Ligand LCR
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Wikipedia Levocetirizine