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ChEMBL ligand: CHEMBL565612 (Sotrastaurin, AEB071, NVP-AEB071, Aeb-071, AEB-071) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Inhibition of human recombinant Alk | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
ChEMBL | Inhibition of human recombinant JNK1 | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
ChEMBL | Inhibition of human recombinant JNK2 | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
ChEMBL | Inhibition of human recombinant JNK3 | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
ChEMBL | Inhibition of human recombinant CDK2/cyclin A | B | 5.64 | pIC50 | 2300 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] | ||||||||
ChEMBL | Inhibition of human recombinant EphB4 | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of human recombinant HER1 | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
ChEMBL | Inhibition of human recombinant FAK | B | 5.08 | pIC50 | 8300 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of human recombinant GSK3-beta | B | 6.06 | pIC50 | 870 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of human recombinant Met | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
ChEMBL | Inhibition of human recombinant IGF1R | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of human recombinant InsR | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of human recombinant p38alpha | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
ChEMBL | Inhibition of human recombinant PI3Kalpha | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
ChEMBL | Inhibition of human recombinant PI3Kbeta | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
ChEMBL | Inhibition of human recombinant PI3Kdelta | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
ChEMBL | Inhibition of human recombinant PI3Kgamma | B | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
ChEMBL | Inhibition of PKCalpha by SPA | B | 8.68 | pIC50 | 2.1 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
ChEMBL | Inhibition of PKCalpha by scintillation proximity assay | B | 8.68 | pIC50 | 2.1 | nM | IC50 | J. Med. Chem. (2011) 54: 6028-6039 [PMID:21797275] |
ChEMBL | Inhibition of PKCalpha (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay | B | 8.68 | pIC50 | 2.1 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 781-786 [PMID:28131714] |
GtoPdb | - | - | 8.68 | pIC50 | 2.1 | nM | IC50 | J Med Chem (2009) 52: 6193-6 [PMID:19827831] |
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
ChEMBL | Inhibition of PKCbeta1 by SPA | B | 8.7 | pIC50 | 2 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
ChEMBL | Inhibition of PKCbeta-1 by scintillation proximity assay | B | 8.7 | pIC50 | 2 | nM | IC50 | J. Med. Chem. (2011) 54: 6028-6039 [PMID:21797275] |
ChEMBL | Inhibition of PKCbeta1 (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assay | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 781-786 [PMID:28131714] |
GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2009) 52: 6193-6 [PMID:19827831] |
protein kinase C beta/Protein kinase C beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3042] [GtoPdb: 1483] [UniProtKB: P68404] | ||||||||
ChEMBL | Inhibition of PKCbeta in mouse B cells assessed as reduction in IgM-stimulated cell proliferation | B | 6.63 | pIC50 | 234 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 781-786 [PMID:28131714] |
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
ChEMBL | Inhibition of PKCdelta by SPA | B | 8.89 | pIC50 | 1.3 | nM | IC50 | J. Med. Chem. (2009) 52: 6193-6196 [PMID:19827831] |
ChEMBL | Inhibition of PKCdelta by scintillation proximity assay | B | 8.89 | pIC50 | 1.3 | nM | IC50 |