alendronate [Ligand Id: 3141] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL870 (Alendronate, Alendronic Acid, Fosamax, Binosto)
  • farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
There should be some charts here, you may need to enable JavaScript!
  • Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 B 6.41 pKi 393.1 nM Ki J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand B 7.04 pKi 91 nM Ki J. Med. Chem. (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins B 7.35 pKi 44.2 nM Ki J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 B 5.65 pIC50 2249 nM IC50 J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) B 6.02 pIC50 954.99 nM IC50 J. Med. Chem. (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase was determined B 6.02 pIC50 950 nM IC50 J. Med. Chem. (2003) 46: 5171-5183 [PMID:14613320]
GtoPdb - - 6.34 pIC50 460 nM IC50 Arch. Biochem. Biophys. (2000) 373: 231-41 [PMID:10620343]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins B 6.59 pIC50 260 nM IC50 J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb In vitro inhibition of recombinant human protein expressed in E coli. - 7.3 pIC50 50 nM IC50 J. Pharmacol. Exp. Ther. (2001) 296: 235-42 [PMID:11160603]
ChEMBL Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme B 7.3 pIC50 50 nM IC50 J. Med. Chem. (2002) 45: 2185-2196 [PMID:12014956]
ChEMBL Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting B 7.3 pIC50 50 nM IC50 J. Med. Chem. (2011) 54: 5955-5980 [PMID:21780776]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL Binding affinity towards Farnesyl diphosphate synthase from leishmania major B 7.02 pKi 95 nM Ki J. Med. Chem. (2005) 48: 2957-2963 [PMID:15828834]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]