alendronate [Ligand Id: 3141] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL870
  • farnesyl diphosphate synthase in Human [GtoPdb: 644] [UniProtKB: P14324]
  • This target only has 0 pki data point
  • 0
1 CHEMBL870_lig_chart_1 farnesyl diphosphate synthase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
farnesyl diphosphate synthase in Human [GtoPdb: 644] [UniProtKB: P14324]
GtoPdb - - 6.34 pIC50 460 nM IC50 Arch Biochem Biophys (2000) 373: 231-41 [PMID:10620343]
GtoPdb In vitro inhibition of recombinant human protein expressed in E coli. - 7.3 pIC50 50 nM IC50 J Pharmacol Exp Ther (2001) 296: 235-42 [PMID:11160603]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]