alendronate [Ligand Id: 3141] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL870 (Alendronate, Alendronic acid, Fosamax, Alendronic Acid, Binosto)
  • farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
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  • Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 B 6.41 pKi 393.1 nM Ki J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand B 7.04 pKi 91 nM Ki J. Med. Chem. (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins B 7.35 pKi 44.2 nM Ki J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 B 5.65 pIC50 2249 nM IC50 J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) B 6.02 pIC50 954.99 nM IC50 J. Med. Chem. (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL Inhibitory activity against farnesyl Pyrophosphate Synthase was determined B 6.02 pIC50 950 nM IC50 J. Med. Chem. (2003) 46: 5171-5183 [PMID:14613320]
GtoPdb - - 6.34 pIC50 460 nM IC50 Arch Biochem Biophys (2000) 373: 231-41 [PMID:10620343]
ChEMBL Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins B 6.59 pIC50 260 nM IC50 J. Med. Chem. (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb In vitro inhibition of recombinant human protein expressed in E coli. - 7.3 pIC50 50 nM IC50 J Pharmacol Exp Ther (2001) 296: 235-42 [PMID:11160603]
ChEMBL Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme B 7.3 pIC50 50 nM IC50 J. Med. Chem. (2002) 45: 2185-2196 [PMID:12014956]
ChEMBL Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting B 7.3 pIC50 50 nM IC50 J. Med. Chem. (2011) 54: 5955-5980 [PMID:21780776]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL Binding affinity towards Farnesyl diphosphate synthase from leishmania major B 7.02 pKi 95 nM Ki J. Med. Chem. (2005) 48: 2957-2963 [PMID:15828834]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]