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ChEMBL ligand: CHEMBL870 (Alendronate, Alendronic acid, Alendronic Acid, Binosto, Fosamax) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 6.41 | pKi | 393.1 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand | B | 7.04 | pKi | 91 | nM | Ki | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 7.35 | pKi | 44.2 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 5.65 | pIC50 | 2249 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) | B | 6.02 | pIC50 | 954.99 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase was determined | B | 6.02 | pIC50 | 950 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
GtoPdb | - | - | 6.34 | pIC50 | 460 | nM | IC50 | Arch Biochem Biophys (2000) 373: 231-41 [PMID:10620343] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
GtoPdb | In vitro inhibition of recombinant human protein expressed in E coli. | - | 7.3 | pIC50 | 50 | nM | IC50 | J Pharmacol Exp Ther (2001) 296: 235-42 [PMID:11160603] |
ChEMBL | Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2002) 45: 2185-2196 [PMID:12014956] |
ChEMBL | Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2011) 54: 5955-5980 [PMID:21780776] |
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] | ||||||||
ChEMBL | Binding affinity towards Farnesyl diphosphate synthase from leishmania major | B | 7.02 | pKi | 95 | nM | Ki | J Med Chem (2005) 48: 2957-2963 [PMID:15828834] |
Farnesyl pyrophosphate synthase in Leishmania major (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150832] [UniProtKB: Q4QBL1] | ||||||||
ChEMBL | Inhibition of recombinant Leishmania major FPPS expressed in Escherichia coli BL21(DE3) using GPP and [14C]IPP as substrate incubated for 15 mins by scintillation counting method | B | 7.04 | pKi | 91 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 127577-127577 [PMID:32979487] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]