ChEMBL ligand: CHEMBL1094250
BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415] There should be some charts here, you may need to enable JavaScript!
Bcl-2-like 1/Apoptosis regulator Bcl-X in Human [ChEMBL: CHEMBL4625] [GtoPdb: 2845] [UniProtKB: Q07817] There should be some charts here, you may need to enable JavaScript!
Bcl-2-related protein A1 in Human [ChEMBL: CHEMBL6044] [UniProtKB: Q16548] There should be some charts here, you may need to enable JavaScript!
MCL1 apoptosis regulator, BCL2 family member/Induced myeloid leukemia cell differentiation protein Mcl-1 in Human [ChEMBL: CHEMBL4361] [GtoPdb: 2847] [UniProtKB: Q07820] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
ChEMBL	Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assay	B	5.94	pIC50	1140	nM	IC50	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]
ChEMBL	Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assay	B	6.49	pIC50	320	nM	IC50	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]
ChEMBL	Inhibition of BH3 peptide binding to Bcl-2 (unknown origin)	B	6.49	pIC50	320	nM	IC50	Eur J Med Chem (2020) 201: 112446-112446 [PMID:32563811]
Bcl-2-like 1/Apoptosis regulator Bcl-X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4625] [GtoPdb: 2845] [UniProtKB: Q07817]
ChEMBL	Binding affinity to Bcl-XL by isothermal titration calorimetric assay	B	5.62	pKd	2400	nM	Kd	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]
ChEMBL	Binding affinity to Bcl-XL by isothermal titration calorimetric assay	B	7	pKd	100	nM	Kd	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]
ChEMBL	Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assay	B	6.17	pIC50	680	nM	IC50	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]
ChEMBL	Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assay	B	6.51	pIC50	310	nM	IC50	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]
ChEMBL	Inhibition of BH3 peptide binding to Bcl-xL (unknown origin)	B	6.51	pIC50	310	nM	IC50	Eur J Med Chem (2020) 201: 112446-112446 [PMID:32563811]
Bcl-2-related protein A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6044] [UniProtKB: Q16548]
ChEMBL	Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assay	B	6.21	pIC50	620	nM	IC50	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]
ChEMBL	Inhibition of BH3 peptide binding to Bfl-1 (unknown origin)	B	6.21	pIC50	620	nM	IC50	Eur J Med Chem (2020) 201: 112446-112446 [PMID:32563811]
ChEMBL	Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assay	B	6.23	pIC50	590	nM	IC50	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]
MCL1 apoptosis regulator, BCL2 family member/Induced myeloid leukemia cell differentiation protein Mcl-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4361] [GtoPdb: 2847] [UniProtKB: Q07820]
ChEMBL	Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assay	B	6.7	pIC50	200	nM	IC50	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]
ChEMBL	Inhibition of BH3 peptide binding to Mcl-1 (unknown origin)	B	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2020) 201: 112446-112446 [PMID:32563811]
ChEMBL	Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assay	B	6.74	pIC50	180	nM	IC50	J Med Chem (2010) 53: 4166-4176 [PMID:20443627]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]