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MCL1 apoptosis regulator, BCL2 family member

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Target not currently curated in GtoImmuPdb

Target id: 2847

Nomenclature: MCL1 apoptosis regulator, BCL2 family member

Abbreviated Name: Mcl-1

Family: B-cell lymphoma 2 (Bcl-2) protein family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 350 1q21.2 MCL1 MCL1 apoptosis regulator, BCL2 family member
Mouse 1 331 3 40.74 cM Mcl1 myeloid cell leukemia sequence 1
Rat 1 330 2q34 Mcl1 MCL1 apoptosis regulator, BCL2 family member
Previous and Unofficial Names Click here for help
MCL1 apoptosis regulator | BCL2 family apoptosis regulator | MCL1 | MCL1, BCL2 family apoptosis regulator | myeloid cell leukemia 1
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
venetoclax Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Antagonist <6.3 pKi 1
pKi <6.3 (Ki >4.44x10-7 M) [1]
obatoclax Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Antagonist 5.5 pKi 2
pKi 5.5 (Ki 2.9x10-6 M) [2]
Description: In vitro antagonism determined in a fluorescence polarisation assay.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0019221 cytokine-mediated signaling pathway TAS
GO:0034097 response to cytokine IDA

References

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1. Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, Dayton BD, Ding H, Enschede SH, Fairbrother WJ et al.. (2013) ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med, 19 (2): 202-8. [PMID:23291630]

2. Wan Y, Dai N, Tang Z, Fang H. (2018) Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents. Eur J Med Chem, 146: 471-482. [PMID:29407973]

How to cite this page

B-cell lymphoma 2 (Bcl-2) protein family: MCL1 apoptosis regulator, BCL2 family member. Last modified on 26/06/2020. Accessed on 23/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2847.