Synonyms: Aplidin® | aplidine | Dehydrodidemnin B
plitidepsin is an approved drug
Compound class:
Natural product or derivative
Comment: Plitidepsin was isolated from the sea squirt Aplidium albicans. It was found to have potent anti-tumour activity, that is mediated via modulation of human elongation factor 1-α (eEF1A) proteins and the translation process. Plitidepsin is also an immunomodulator and has antiviral properties.
SARS-CoV-2: The coronavirus exploits the eukaryotic (host) translation machinery to allow it to replicate. As a translation disruptor, plitidepsin has demonstrated in vivo anti-SARS-CoV-2 activity in mouse models of infection [1]. Under in vitro experimental conditions plitidepsin inhibited SARS-CoV-2 replication more effectively than remdesivir. |
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Classification | |
Compound class | Natural product or derivative |
Approved drug? | Yes |
International Nonproprietary Names | |
INN number | INN |
8549 | plitidepsin |
Synonyms |
Aplidin® | aplidine | Dehydrodidemnin B |
Database Links | |
CAS Registry No. | 137219-37-5 (source: WHO INN record) |
DrugBank Ligand | DB04977 |
GtoPdb PubChem SID | 440816765 |
PubChem CID | 9812534 |
RCSB PDB Ligand | ZIY |
Search Google for chemical match using the InChIKey | UUSZLLQJYRSZIS-LXNNNBEUSA-N |
Search Google for chemicals with the same backbone | UUSZLLQJYRSZIS |
Search PubMed clinical trials | plitidepsin |
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UniChem Compound Search for chemical match using the InChIKey | UUSZLLQJYRSZIS-LXNNNBEUSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | UUSZLLQJYRSZIS-LXNNNBEUSA-N |