sofosbuvir [Ligand Id: 7368] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1259059 (GS-7977, GS7977, PSI-7977, Psi-7977, gs-7977, Sofosbuvir, Sovaldi)
  • Cereblon isoform 4 in Magnetospirillum gryphiswaldense [ChEMBL: CHEMBL3763007] [UniProtKB: A4TVL0]
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  • RNA-directed RNA polymerase in Hepacivirus hominis [ChEMBL: CHEMBL4296320] [UniProtKB: O39930]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cereblon isoform 4 in Magnetospirillum gryphiswaldense (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763007] [UniProtKB: A4TVL0]
ChEMBL Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measuring baseline corrected normalized fluorescence by MST based assay B 4.57 pKi 27000 nM Ki ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967]
ChEMBL Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform by FRET assay B 4.66 pKi 22000 nM Ki ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967]
Nonstructural protein 5 in Dengue virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295629] [UniProtKB: V5TFZ2]
ChEMBL Inhibition of Dengue virus NS5/RNA-dependent RNA polymerase B 4.83 pIC50 14700 nM IC50 Eur J Med Chem (2023) 256: 115416-115416 [PMID:37159959]
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus infected in African green monkey Vero cells assessed as antiviral activity by DAPI-staining based assay B 4.51 pEC50 30900 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus infected in human NPC assessed as antiviral activity by DAPI-staining based assay B 6.92 pEC50 120 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
RNA-directed RNA polymerase in Hepacivirus hominis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296320] [UniProtKB: O39930]
ChEMBL Inhibition of NS5B S282T mutant in HCV genotype 1b replicon expressed in human HuH7 cells after 72 hrs by bright Glo-luciferase reporter gene assay B 6.23 pEC50 589 nM EC50 J Med Chem (2017) 60: 6077-6088 [PMID:28650160]
ChEMBL Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assay B 6.52 pEC50 300 nM EC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]
ChEMBL Inhibition of NS5B polymerase in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay B 6.64 pEC50 230 nM EC50 Bioorg Med Chem Lett (2020) 30: 126986-126986 [PMID:32046903]
ChEMBL Inhibition of NS5B polymerase in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay B 6.81 pEC50 155 nM EC50 Bioorg Med Chem Lett (2020) 30: 126986-126986 [PMID:32046903]
ChEMBL Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase B 6.99 pEC50 102 nM EC50 Medchemcomm (2019) 10: 991-1006 [PMID:31303998]
ChEMBL Inhibition of Hepatitis C virus genotype 1b NS5B RNA-dependent-RNA polymerase assessed as reduction in viral replication after 72 hrs by indirect immunofluorescence assay B 7.19 pEC50 64.26 nM EC50 Bioorg Med Chem (2018) 26: 2621-2631 [PMID:29681484]
ChEMBL Inhibition of NS5B polymerase in HCV genotype 1b/3a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysis B 7.19 pEC50 64 nM EC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]
ChEMBL Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 5 days by RT-PCR analysis B 7.21 pEC50 61 nM EC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]
ChEMBL Inhibition of NS5B polymerase in HCV genotype 1b/4a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysis B 7.24 pEC50 58 nM EC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]
ChEMBL Inhibition of NS5B polymerase in HCV genotype 1b/5a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysis B 7.36 pEC50 44 nM EC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]
ChEMBL Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 5 days by RT-PCR analysis B 7.37 pEC50 43 nM EC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]
ChEMBL Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assay B 7.47 pEC50 34 nM EC50 J Med Chem (2019) 62: 1859-1874 [PMID:30653317]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]