ME-1228 acid   Click here for help

GtoPdb Ligand ID: 11045

Synonyms: ME1228
Compound class: Synthetic organic
Comment: ME1228 is a parenteral cephalosporin antibacterial [2]. It is sensitive to hydrolysis by TEM-3 and Xanthomonas maltophilia β-lactamases.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 12
Topological polar surface area 267.23
Molecular weight 593.09
XLogP 0.1
No. Lipinski's rules broken 1
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Canonical SMILES CC[n+]1ccc(cc1)SCC1=C(C(=O)O)N2[C@H](SC1)[C@@H](C2=O)NC(=O)/C(=N/O[C@H](C(=O)O)C)/c1csc(n1)N
Isomeric SMILES CC[n+]1ccc(cc1)SCC1=C(C(=O)O)N2[C@H](SC1)[C@@H](C2=O)NC(=O)/C(=N/O[C@H](C(=O)O)C)/c1csc(n1)N
InChI InChI=1S/C23H24N6O7S3/c1-3-28-6-4-13(5-7-28)37-8-12-9-38-20-16(19(31)29(20)17(12)22(34)35)26-18(30)15(14-10-39-23(24)25-14)27-36-11(2)21(32)33/h4-7,10-11,16,20H,3,8-9H2,1-2H3,(H4-,24,25,26,30,32,33,34,35)/p+1/b27-15+/t11-,16+,20+/m0/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1S)-1-carboxyethoxy]iminoacetyl]amino]-3-[(1-ethylpyridin-1-ium-4-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo ME1228 (sulphur analogue of OCP9176)
Other databases
GtoPdb PubChem SID 405560486
PubChem CID 9577435
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