ChEMBL ligand: CHEMBL225304 (Aminoguanidine, Pimagedine)
aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!
Diamine oxidase in Human [ChEMBL: CHEMBL2118] [UniProtKB: P19801] There should be some charts here, you may need to enable JavaScript!
Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] Neuronal NOS/Nitric-oxide synthase, brain in Rat [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] There should be some charts here, you may need to enable JavaScript!
Endothelial NOS/Nitric-oxide synthase, endothelial in Human [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] There should be some charts here, you may need to enable JavaScript!
Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] Inducible NOS/Nitric oxide synthase, inducible in Mouse [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	Inhibition of Sprague-Dawley rat lens aldose reductase	B	4.52	pIC50	>30000	nM	IC50	J Nat Prod (2012) 75: 267-270 [PMID:22264115]
Diamine oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2118] [UniProtKB: P19801]
ChEMBL	Tested for ability to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assay	B	6.85	pKi	140	nM	Ki	Bioorg Med Chem Lett (1993) 3: 353-356
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL	Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline	B	5.48	pKi	3300	nM	Ki	Bioorg Med Chem (2008) 16: 6193-6206 [PMID:18477512]
ChEMBL	Inhibitory activity against human neuronal nitric oxide synthase	B	5.23	pIC50	5900	nM	IC50	J Med Chem (2003) 46: 913-916 [PMID:12620067]
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
ChEMBL	Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visible spectrophotometer analysis	B	4.71	pIC50	19410	nM	IC50	Bioorg Med Chem (2011) 19: 3935-3944 [PMID:21665485]
ChEMBL	Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum	F	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580]
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
ChEMBL	Inhibitory activity against human endothelial nitric oxide synthase	B	4	pIC50	100000	nM	IC50	J Med Chem (2003) 46: 913-916 [PMID:12620067]
ChEMBL	Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells	F	4.14	pIC50	72000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.	B	4.27	pIC50	54000	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1573-1576
ChEMBL	Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells	F	5.35	pIC50	4500	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580]
ChEMBL	Inhibitory activity of compound against human inducible nitric oxide synthase	B	5.41	pIC50	3900	nM	IC50	J Med Chem (2003) 46: 913-916 [PMID:12620067]
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477]
ChEMBL	Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method	B	4.55	pIC50	28470	nM	IC50	J Nat Prod (2011) 74: 2489-2496 [PMID:22148193]
ChEMBL	Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs	B	4.58	pIC50	26550	nM	IC50	J Nat Prod (2011) 74: 1875-1880 [PMID:21846089]
ChEMBL	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells	B	5.05	pIC50	9000	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1573-1576

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]