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ChEMBL ligand: CHEMBL225304 (Aminoguanidine, Pimagedine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
ChEMBL | Inhibition of Sprague-Dawley rat lens aldose reductase | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Nat Prod (2012) 75: 267-270 [PMID:22264115] |
Diamine oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2118] [UniProtKB: P19801] | ||||||||
ChEMBL | Tested for ability to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assay | B | 6.85 | pKi | 140 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 353-356 |
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
ChEMBL | Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline | B | 5.48 | pKi | 3300 | nM | Ki | Bioorg Med Chem (2008) 16: 6193-6206 [PMID:18477512] |
ChEMBL | Inhibitory activity against human neuronal nitric oxide synthase | B | 5.23 | pIC50 | 5900 | nM | IC50 | J Med Chem (2003) 46: 913-916 [PMID:12620067] |
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
ChEMBL | Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visible spectrophotometer analysis | B | 4.71 | pIC50 | 19410 | nM | IC50 | Bioorg Med Chem (2011) 19: 3935-3944 [PMID:21665485] |
ChEMBL | Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum | F | 5.22 | pIC50 | 6000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580] |
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
ChEMBL | Inhibitory activity against human endothelial nitric oxide synthase | B | 4 | pIC50 | 100000 | nM | IC50 | J Med Chem (2003) 46: 913-916 [PMID:12620067] |
ChEMBL | Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells | F | 4.14 | pIC50 | 72000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580] |
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
ChEMBL | Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells. | B | 4.27 | pIC50 | 54000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 1573-1576 |
ChEMBL | Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells | F | 5.35 | pIC50 | 4500 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580] |
ChEMBL | Inhibitory activity of compound against human inducible nitric oxide synthase | B | 5.41 | pIC50 | 3900 | nM | IC50 | J Med Chem (2003) 46: 913-916 [PMID:12620067] |
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
ChEMBL | Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method | B | 4.55 | pIC50 | 28470 | nM | IC50 | J Nat Prod (2011) 74: 2489-2496 [PMID:22148193] |
ChEMBL | Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs | B | 4.58 | pIC50 | 26550 | nM | IC50 | J Nat Prod (2011) 74: 1875-1880 [PMID:21846089] |
ChEMBL | Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells | B | 5.05 | pIC50 | 9000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 1573-1576 |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]