ChEMBL ligand: CHEMBL225304 (Aminoguanidine, Pimagedine)
aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!
Diamine oxidase in Human [ChEMBL: CHEMBL2118] [UniProtKB: P19801] There should be some charts here, you may need to enable JavaScript!
Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] Neuronal NOS/Nitric-oxide synthase, brain in Rat [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] There should be some charts here, you may need to enable JavaScript!
Endothelial NOS/Nitric-oxide synthase, endothelial in Human [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] There should be some charts here, you may need to enable JavaScript!
Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] Inducible NOS/Nitric oxide synthase, inducible in Mouse [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	Inhibition of Sprague-Dawley rat lens aldose reductase	B	4.52	pIC50	>30000	nM	IC50	J Nat Prod (2012) 75: 267-270 [PMID:22264115]
Diamine oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2118] [UniProtKB: P19801]
ChEMBL	Tested for ability to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assay	B	6.85	pKi	140	nM	Ki	Bioorg Med Chem Lett (1993) 3: 353-356
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL	Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrulline	B	5.48	pKi	3300	nM	Ki	Bioorg Med Chem (2008) 16: 6193-6206 [PMID:18477512]
ChEMBL	Inhibitory activity against human neuronal nitric oxide synthase	B	5.23	pIC50	5900	nM	IC50	J Med Chem (2003) 46: 913-916 [PMID:12620067]
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476]
ChEMBL	Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visible spectrophotometer analysis	B	4.71	pIC50	19410	nM	IC50	Bioorg Med Chem (2011) 19: 3935-3944 [PMID:21665485]
ChEMBL	Inhibition of conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum	F	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580]
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
ChEMBL	Inhibitory activity against human endothelial nitric oxide synthase	B	4	pIC50	100000	nM	IC50	J Med Chem (2003) 46: 913-916 [PMID:12620067]
ChEMBL	Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells	F	4.14	pIC50	72000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
ChEMBL	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.	B	4.27	pIC50	54000	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1573-1576
ChEMBL	Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells	F	5.35	pIC50	4500	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1023-1026 [PMID:11327580]
ChEMBL	Inhibitory activity of compound against human inducible nitric oxide synthase	B	5.41	pIC50	3900	nM	IC50	J Med Chem (2003) 46: 913-916 [PMID:12620067]
Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477]
ChEMBL	Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method	B	4.55	pIC50	28470	nM	IC50	J Nat Prod (2011) 74: 2489-2496 [PMID:22148193]
ChEMBL	Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs	B	4.58	pIC50	26550	nM	IC50	J Nat Prod (2011) 74: 1875-1880 [PMID:21846089]
ChEMBL	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells	B	5.05	pIC50	9000	nM	IC50	Bioorg Med Chem Lett (1995) 5: 1573-1576

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]