omeprazole [Ligand Id: 4279] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1503 (Omeran, H-168/68, H 168/68, Prilosec, Mopral, Antra, Losec MUPS, Losec, Mezzopram, Zanprol, Omeprazole)
  • BB3 receptor/Bombesin receptor subtype-3 in Human [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247]
  • This target only has 0 pki data point
1 CHEMBL1503_lig_chart_1 Bombesin receptor subtype-3 Human
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  • Endo-beta-N-acetylglucosaminidase in Human [ChEMBL: CHEMBL5172] [UniProtKB: Q8NFI3]
  • This target only has 0 pki data point
2 CHEMBL1503_lig_chart_2 Endo-beta-N-acetylglucosaminidase Human
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  • fatty acid synthase/Fatty acid synthase in Human [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327]
  • This target only has 1 pki data point
3 CHEMBL1503_lig_chart_3 Fatty acid synthase Human
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  • glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417]
  • This target only has 0 pki data point
4 CHEMBL1503_lig_chart_4 Glutathione transferase omega 1 Human
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  • NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760]
  • This target only has 0 pki data point
5 CHEMBL1503_lig_chart_5 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Human
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  • ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
  • This target only has 0 pki data point
6 CHEMBL1503_lig_chart_6 P-glycoprotein 1 Human
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  • Plasmodium berghei [ChEMBL: CHEMBL612653]
  • This target only has 0 pki data point
7 CHEMBL1503_lig_chart_7 Plasmodium berghei Plasmodium berghei
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
8 CHEMBL1503_lig_chart_8 Plasmodium falciparum Plasmodium falciparum
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9 CHEMBL1503_lig_chart_9 Potassium-transporting ATPase HumanPig
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  • sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4/Sodium/potassium-transporting ATPase in Human [ChEMBL: CHEMBL2095186] [GtoPdb: 8338378358388348392610836] [UniProtKB: P05023P05026P13637P14415P50993P54709P54710Q13733]
  • This target only has 0 pki data point
10 CHEMBL1503_lig_chart_10 Sodium/potassium-transporting ATPase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
BB3 receptor/Bombesin receptor subtype-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4080] [GtoPdb: 40] [UniProtKB: P32247]
ChEMBL Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay F 4.85 pEC50 14000 nM EC50 Bioorg. Med. Chem. Lett. (2008) 18: 5451-5455 [PMID:18818070]
Endo-beta-N-acetylglucosaminidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5172] [UniProtKB: Q8NFI3]
ChEMBL Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreated for 15 mins followed by substrate addition after 90 mins by SDS-PAGE analysis B 4.6 pIC50 25000 nM IC50 Bioorg Med Chem Lett (2017) 27: 2962-2966 [PMID:28512024]
fatty acid synthase/Fatty acid synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4158] [GtoPdb: 2608] [UniProtKB: P49327]
ChEMBL Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition measured after 1 hr by fluorescence assay B 5.47 pKi 3400 nM Ki J. Med. Chem. (2015) 58: 778-784 [PMID:25513712]
ChEMBL Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition measured after 1 hr by fluorescence assay B 4.53 pIC50 29600 nM IC50 J. Med. Chem. (2015) 58: 778-784 [PMID:25513712]
glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417]
ChEMBL Inhibition of GSTO1-1 (unknown origin) by enzymatic assay B 5.34 pIC50 4600 nM IC50 J Med Chem (2018) 61: 7448-7470 [PMID:29652143]
NG,NG-Dimethylarginine dimethylaminohydrolase 1/N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6036] [GtoPdb: 1247] [UniProtKB: O94760]
ChEMBL Inhibition of recombinant human DDAH1 expressed in Escherichia coli BL21 Star (DE3) using ADMA as substrate assessed as decrease in citrulline production after 4 hrs by colorimetric method B 4.7 pIC50 20000 nM IC50 WO-2014160947-A1. Dimethylarginine Dimethylaminohydrolase inhibitors and methods of use thereof (2014)
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model B 4.01 pIC50 97200 nM IC50 J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model B 4.04 pIC50 91200 nM IC50 J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity model B 4.05 pIC50 89000 nM IC50 J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells F 4.75 pIC50 17700 nM IC50 Naunyn Schmiedebergs Arch. Pharmacol. (2001) 364: 551-557 [PMID:11770010]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells F 6.17 pIC50 680 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 4.12 pIC50 76000 nM IC50 Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL HARVARD: Inhibition of blood stage Plasmodium falciparum 3D7 infection F 4.3 pIC50 >50000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
ChEMBL HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection F 4.3 pIC50 >50000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
ChEMBL DNDI: Malaria in Vitro, 72 hour F 4.88 pIC50 13230 nM IC50 Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
ATP4A/ATP4B/Potassium-transporting ATPase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095173] [GtoPdb: 849851] [UniProtKB: P20648P51164]
ChEMBL Compound was tested in vitro for H+/K+ ATPase activity in rabbit stomach preparations B 4.65 pIC50 22400 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 2819-2822 [PMID:10522698]
ChEMBL Inhibition of H+/K+ ATPase activity in buffered solution (pH 7.4) B 5.42 pIC50 3800 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 1909-1912 [PMID:9873457]
ChEMBL In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosa B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (1988) 31: 1215-1220 [PMID:2836591]
ChEMBL In vitro evaluation for the inhibition of H+/K+ ATPase at pH < 3 in the gastric glands of isolated rabbit stomach. B 6.3 pIC50 501.19 nM IC50 J. Med. Chem. (1992) 35: 1049-1057 [PMID:1313110]
ChEMBL Inhibition of [14C]aminopyrine (AP) accumulation stimulated by dibutyryl cyclic AMP in isolated rabbit parietal cells F 6.43 pIC50 370 nM IC50 J. Med. Chem. (1997) 40: 313-321 [PMID:9022797]
ChEMBL Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5' -monophosphate (dcAMP) F 6.55 pIC50 280 nM IC50 J. Med. Chem. (1988) 31: 1778-1785 [PMID:2842503]
ChEMBL Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine F 6.6 pIC50 250 nM IC50 J. Med. Chem. (1988) 31: 1778-1785 [PMID:2842503]
Potassium-transporting ATPase in Pig (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095228] [UniProtKB: P18434P19156]
ChEMBL Activity was evaluated by measuring the inhibition of isolated hog H+/K+ ATPase B 4.3 pIC50 50000 nM IC50 J. Med. Chem. (1991) 34: 1049-1062 [PMID:1848293]
ChEMBL In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesicles B 5.42 pIC50 3800 nM IC50 J. Med. Chem. (1996) 39: 596-604 [PMID:8558532]
sodium/potassium-transporting ATPase subunit α-1/sodium/potassium-transporting ATPase subunit β-1/sodium/potassium-transporting ATPase subunit α-3/sodium/potassium-transporting ATPase subunit β-2/sodium/potassium-transporting ATPase subunit α-2/sodium/potassium-transporting ATPase subunit β-3/sodium/potassium-transporting ATPase subunit γ/sodium/potassium-transporting ATPase subunit α-4/Sodium/potassium-transporting ATPase in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095186] [GtoPdb: 8338378358388348392610836] [UniProtKB: P05023P05026P13637P14415P50993P54709P54710Q13733]
ChEMBL In vitro evaluation for its ability to inhibit the Na+/K+ ATPase at pH 7.4. B 4.5 pIC50 31622.78 nM IC50 J. Med. Chem. (1992) 35: 1049-1057 [PMID:1313110]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]