fatty acid synthase | 2.3.1.- Acyltransferases | IUPHAR/BPS Guide to PHARMACOLOGY

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fatty acid synthase

Target not currently curated in GtoImmuPdb

Target id: 2608

Nomenclature: fatty acid synthase

Family: 2.3.1.- Acyltransferases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2511 17q25 FASN fatty acid synthase
Mouse - 2504 11 E2 Fasn fatty acid synthase
Rat - 2505 10 Fasn fatty acid synthase
Previous and Unofficial Names
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  X-ray structure of human Fatty Acid Synthase Psi/KR Tri-Domain complexed with NADPH and GSK2194069.
Ligand:  GSK2194069
Resolution:  2.3Å
Species:  Human
References:  1
Enzyme Reaction
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GSK2194069 Hs Inhibition 8.1 pIC50 1
pIC50 8.1 (IC50 7.7x10-9 M) [1]
Immuno Process Associations
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0030223 neutrophil differentiation IEA
GO:0030224 monocyte differentiation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0071353 cellular response to interleukin-4 IEA


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1. Hardwicke MA, Rendina AR, Williams SP, Moore ML, Wang L, Krueger JA, Plant RN, Totoritis RD, Zhang G, Briand J et al.. (2014) A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat. Chem. Biol., 10 (9): 774-9. [PMID:25086508]

How to cite this page

2.3.1.- Acyltransferases: fatty acid synthase. Last modified on 13/08/2015. Accessed on 02/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2608.