ChEMBL ligand: CHEMBL455876 (24-Dehydrocholesterol, Desmosterol)
RAR-related orphan receptor-γ/Nuclear receptor ROR-gamma in Human [ChEMBL: CHEMBL1741186] [GtoPdb: 600] [UniProtKB: P51449] There should be some charts here, you may need to enable JavaScript!
Liver X receptor-β in Human [GtoPdb: 601] [UniProtKB: P55055] There should be some charts here, you may need to enable JavaScript!
Liver X receptor-α in Human [GtoPdb: 602] [UniProtKB: Q13133] There should be some charts here, you may need to enable JavaScript!
Farnesoid X receptor-β in Mouse [GtoPdb: 604] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
RAR-related orphan receptor-γ/Nuclear receptor ROR-gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741186] [GtoPdb: 600] [UniProtKB: P51449]
ChEMBL	Agonist activity at Gal4-fused RORgammat DNA binding domain (unknown origin) expressed in 293T cells assessed as SRC1 coactivator recruitment in presence of ursolic acid by TR-FRET assay	B	7.1	pEC50	80	nM	EC50	J Med Chem (2018) 61: 5794-5804 [PMID:29412659]
ChEMBL	Orthosteric agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in coactivator, N-terminal biotinylated SRC-1 box2 peptide recruitment incubated for 60 mins by TR-FRET assay	B	7.32	pEC50	48	nM	EC50	ACS Med Chem Lett (2021) 12: 631-639 [PMID:33854703]
Liver X receptor-β in Human [GtoPdb: 601] [UniProtKB: P55055]
GtoPdb	-	-	5.85	pKi	1400	nM	Ki	J Biol Chem (2006) 281: 27816-26 [PMID:16857673]
Liver X receptor-α in Human [GtoPdb: 602] [UniProtKB: Q13133]
GtoPdb	-	-	5.54	pKi	2900	nM	Ki	J Biol Chem (2006) 281: 27816-26 [PMID:16857673]
Farnesoid X receptor-β in Mouse [GtoPdb: 604]
GtoPdb	-	-	5	pEC50	-	-	-	Mol Cell Biol (2003) 23: 864-72 [PMID:12529392]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]