tacedinaline [Ligand Id: 8367] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL235191 (Tacedinaline, GOE-5549, CI-994, PD-123654)
  • histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
1 CHEMBL235191_lig_chart_1 Histone deacetylase 1 Human
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
2 CHEMBL235191_lig_chart_2 Histone deacetylase 2 Human
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
3 CHEMBL235191_lig_chart_3 Histone deacetylase 3 Human
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
  • This target only has 0 pki data point
4 CHEMBL235191_lig_chart_4 Histone deacetylase 6 Human
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
  • This target only has 0 pki data point
5 CHEMBL235191_lig_chart_5 Histone deacetylase 8 Human
There should be some charts here, you may need to enable JavaScript!
  • Nicotinamide phosphoribosyltransferase in Human [ChEMBL: CHEMBL1744525] [UniProtKB: P43490]
  • This target only has 0 pki data point
6 CHEMBL235191_lig_chart_6 Nicotinamide phosphoribosyltransferase Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
GtoPdb - - 7.3 pKi 50 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of human HDAC1 B 7.3 pKi 50 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of HDAC1 (unknown origin) by fluorimetric assay B 4.74 pIC50 18220 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 154-159 [PMID:26611919]
ChEMBL Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate by fluorometric assay B 5.79 pIC50 1620 nM IC50 Eur J Med Chem (2017) 134: 1-12 [PMID:28391133]
ChEMBL Inhibition of human recombinant HDAC1 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by fluorescence assay B 5.79 pIC50 1620 nM IC50 Eur J Med Chem (2018) 143: 320-333 [PMID:29202397]
ChEMBL Inhibition of human recombinant HDAC1 (1 to 482 residues) expressed in Baculovirus using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence assay B 5.92 pIC50 1200 nM IC50 J Med Chem (2017) 60: 7965-7983 [PMID:28885834]
ChEMBL Inhibition of human recombinant full length HDAC1 using fluorogenic substrate 3 after 30 mins by fluorescence assay B 5.96 pIC50 1090 nM IC50 J Med Chem (2018) 61: 7245-7260 [PMID:30045621]
ChEMBL Inhibition of human recombinant HDAC1 B 6.05 pIC50 900 nM IC50 J. Med. Chem. (2007) 50: 5543-5546 [PMID:17941625]
GtoPdb - - 6.24 pIC50 570 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 973-8 [PMID:18182289]
ChEMBL Inhibition of HDAC1 B 6.24 pIC50 570 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 973-978 [PMID:18182289]
ChEMBL Inhibition of human recombinant HDAC1 (1 to 482 residues) expressed in Baculovirus using Ac-Leu-Gly-Lys(Ac)-AMC as substrate after 3 hrs by fluorescence assay B 7.22 pIC50 60 nM IC50 J Med Chem (2017) 60: 7965-7983 [PMID:28885834]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
ChEMBL Inhibition of human HDAC2 B 6.72 pKi 190 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
GtoPdb - - 6.82 pKi 150 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of HDAC2 (unknown origin) by fluorimetric assay B 5.41 pIC50 3850 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 154-159 [PMID:26611919]
ChEMBL Inhibition of human recombinant HDAC2 using Fluor de Lys green as substrate by fluorometric assay B 5.92 pIC50 1200 nM IC50 Eur J Med Chem (2017) 134: 1-12 [PMID:28391133]
ChEMBL Inhibition of human recombinant HDAC2 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by fluorescence assay B 5.92 pIC50 1200 nM IC50 Eur J Med Chem (2018) 143: 320-333 [PMID:29202397]
ChEMBL Inhibition of human recombinant HDAC2 B 6.05 pIC50 900 nM IC50 J. Med. Chem. (2007) 50: 5543-5546 [PMID:17941625]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL Inhibition of human HDAC3 B 6.26 pKi 550 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
GtoPdb - - 6.26 pKi 550 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of HDAC3 (unknown origin) by fluorimetric assay B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 154-159 [PMID:26611919]
ChEMBL Inhibition of human recombinant HDAC3 B 5.92 pIC50 1200 nM IC50 J. Med. Chem. (2007) 50: 5543-5546 [PMID:17941625]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL Inhibition of HDAC6 (unknown origin) by fluorimetric assay B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 154-159 [PMID:26611919]
ChEMBL Inhibition of human recombinant HDAC6 using Fluor de Lys as substrate after 60 mins by fluorometric assay B 4.4 pIC50 >40000 nM IC50 Eur J Med Chem (2017) 134: 1-12 [PMID:28391133]
ChEMBL Inhibition of human recombinant HDAC6 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by fluorescence assay B 4.4 pIC50 >40000 nM IC50 Eur J Med Chem (2018) 143: 320-333 [PMID:29202397]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
ChEMBL Inhibition of human recombinant HDAC8 B 4.7 pIC50 >20000 nM IC50 J. Med. Chem. (2007) 50: 5543-5546 [PMID:17941625]
Nicotinamide phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1744525] [UniProtKB: P43490]
ChEMBL Inhibition of human recombinant NAMPT using NAM as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins by fluorescence assay B 5.7 pIC50 >2000 nM IC50 J Med Chem (2017) 60: 7965-7983 [PMID:28885834]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]