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ChEMBL ligand: CHEMBL4846921 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
ChEMBL | Inhibition of CK2alpha1 (unknown origin) | B | 7.86 | pIC50 | 13.9 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
ChEMBL | Inhibition of CDK4 (unknown origin) | B | 8.07 | pIC50 | 8.5 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762] | ||||||||
ChEMBL | Inhibition of EphB1 (unknown origin) | B | 7.53 | pIC50 | 29.8 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345] | ||||||||
ChEMBL | Inhibition of DDR1 (unknown origin) | B | 8.36 | pIC50 | 4.4 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
ChEMBL | Inhibition of FAK (unknown origin) | B | 8.01 | pIC50 | 9.7 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
ChEMBL | Inhibition of recombinant FAK (unknown origin) by radiometric kinase assay | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG by patch-clamp assay | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
ChEMBL | Inhibition of ROS (unknown origin) | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332] | ||||||||
ChEMBL | Inhibition of Fes (unknown origin) | B | 8.31 | pIC50 | 4.9 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Inhibition of Fyn (unknown origin) | B | 8.11 | pIC50 | 7.7 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
ChEMBL | Inhibition of JAK1 (unknown origin) | B | 8.74 | pIC50 | 1.8 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
ChEMBL | Inhibition of JAK3 (unknown origin) | B | 8.49 | pIC50 | 3.2 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of Lck (unknown origin) | B | 8.11 | pIC50 | 7.8 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
ChEMBL | Inhibition of RET (unknown origin) | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibition of Src (unknown origin) | B | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
ChEMBL | Inhibition of TYK2 (unknown origin) | B | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2021) 64: 11934-11957 [PMID:34324343] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]