compound 33 [PMID: 19908842] [Ligand Id: 8874] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL578159 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] | ||||||||
| ChEMBL | Inhibition of human Caspase 1 | B | 4.79 | pIC50 | 16218.1 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
| cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
| ChEMBL | Inhibition of human Cathepsin L | B | 5.1 | pIC50 | 7943.28 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
| cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] | ||||||||
| ChEMBL | Inhibition of human Cathepsin S | B | 4.57 | pIC50 | 26915.35 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
| cathepsin Z/Cathepsin Z in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4160] [GtoPdb: 2354] [UniProtKB: Q9UBR2] | ||||||||
| ChEMBL | Inhibition of human Cathepsin X/Z | B | 4.83 | pIC50 | 14791.08 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
| chymase 1/Chymase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4068] [GtoPdb: 2340] [UniProtKB: P23946] | ||||||||
| ChEMBL | Inhibition of human Chymase | B | 4.05 | pIC50 | 89125.09 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
| Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779] | ||||||||
| ChEMBL | Inhibition of Trypanosoma cruzi cruzain after 15 mins | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
| cathepsin C/Dipeptidyl peptidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634] | ||||||||
| ChEMBL | Inhibition of human Cathepsin C | B | 5.16 | pIC50 | 6918.31 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
| kallikrein related peptidase 4/Kallikrein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4446] [GtoPdb: 2374] [UniProtKB: Q9Y5K2] | ||||||||
| ChEMBL | Inhibition of human Kallikrein 4 | B | 5.01 | pIC50 | 9772.37 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
| GtoPdb | - | - | 5.01 | pIC50 | 9772 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
| elastase, neutrophil expressed/Leukocyte elastase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246] | ||||||||
| ChEMBL | Inhibition of human Elastase | B | 4.07 | pIC50 | 85113.8 | nM | IC50 | J Med Chem (2010) 53: 52-60 [PMID:19908842] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
