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cathepsin Z

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Target not currently curated in GtoImmuPdb

Target id: 2354

Nomenclature: cathepsin Z

Family: C1: Papain

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 303 20q13.32 CTSZ cathepsin Z
Mouse - 306 2 97.94 cM Ctsz cathepsin Z
Rat - 306 3q43 Ctsz cathepsin Z
Previous and Unofficial Names Click here for help
CATX | carboxypeptidase LB | cathepsin B2 | cathepsin IV | cathepsin Y | lysosomal carboxypeptidase B | cathepsin X | CTSX | cysteine-type carboxypeptidase
Database Links Click here for help
Specialist databases
MEROPS C01.013 (Hs)
Other databases
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.18.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
odanacatib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 1x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS

References

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1. Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong le T, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T et al.. (2008) The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett, 18 (3): 923-8. [PMID:18226527]

How to cite this page

C1: Papain: cathepsin Z. Last modified on 28/07/2015. Accessed on 09/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2354.