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latozinemab   Click here for help

GtoPdb Ligand ID: 13685

Synonyms: AL-001 | AL001
Compound class: Antibody
Comment: Latozinemab (AL001) is an anti-sortilin 1 (SORT1) monoclonal antibody. It is proposed to elevate progranulin levels by inhibiting the SORT1-mediated degradation pathway for progranulin (PGRN). This mechanism is being investigated as a disease‐modifying therapy for patients with frontotemporal dementia caused by loss-of-function mutations in GRN.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
11584 latozinemab
Synonyms Click here for help
AL-001 | AL001
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1130
Other databases
GtoPdb PubChem SID 507750319
Search PubMed clinical trials latozinemab
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