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ChEMBL ligand: CHEMBL1305 (Antazoline, Antaz sulf, Atazoline, Vasocon-a, Vasocon-A) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Histamine H1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3943] [UniProtKB: P31389] | ||||||||
ChEMBL | Antagonist potency at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins | F | 7.14 | pKd | 72.44 | nM | Kd | Bioorg Med Chem (2018) 26: 2573-2585 [PMID:29681486] |
ChEMBL | Antagonist activity at H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced ileum contraction measured after 15 mins | B | 7.14 | pKd | 72.44 | nM | Kd | Eur J Med Chem (2018) 152: 223-234 [PMID:29723785] |
ChEMBL | Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions incubated for 15 mins | B | 7.14 | pKd | 72.44 | nM | Kd | Bioorg Med Chem (2017) 25: 5341-5354 [PMID:28797771] |
ChEMBL | Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins | B | 7.14 | pKd | 72.44 | nM | Kd | Bioorg Med Chem (2019) 27: 1254-1262 [PMID:30792106] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]