berberine [Ligand Id: 11353] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL12089 (Berberine chloride, NSC-646666, Berberine hydrochloride, GNF-Pf-4545, NSC-163088)
  • Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
  • This target only has 1 pki data point
  • 0
1 CHEMBL12089_lig_chart_1 Acetylcholinesterase Electrophorus electricusHuman
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
  • This target only has 1 pki data point
  • 6.56
2 CHEMBL12089_lig_chart_2 Alpha-2b adrenergic receptor Human
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  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
  • This target only has 1 pki data point
  • 6.39
3 CHEMBL12089_lig_chart_3 Alpha-2c adrenergic receptor Human
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  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
  • Butyrylcholinesterase in Equus caballus [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9]
  • This target only has 0 pki data point
  • 0
4 CHEMBL12089_lig_chart_4 Butyrylcholinesterase HumanEquus caballus
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  • Cell division protein ftsZ in Escherichia coli K-12 [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6]
  • This target only has 0 pki data point
  • 0
5 CHEMBL12089_lig_chart_5 Cell division protein ftsZ Escherichia coli K-12
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  • Cholinesterase in Equus caballus [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
  • This target only has 1 pki data point
  • 5.04
6 CHEMBL12089_lig_chart_6 Cholinesterase Equus caballus
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  • CYP2D6/Cytochrome P450 2D6 in Human [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
  • This target only has 0 pki data point
  • 0
7 CHEMBL12089_lig_chart_7 Cytochrome P450 2D6 Human
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  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 0 pki data point
  • 0
8 CHEMBL12089_lig_chart_8 HERG Human
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • This target only has 1 pki data point
  • 6.13
9 CHEMBL12089_lig_chart_9 Muscarinic acetylcholine receptor M1 Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
10 CHEMBL12089_lig_chart_10 Plasmodium falciparum Plasmodium falciparum
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
  • This target only has 0 pki data point
  • 0
11 CHEMBL12089_lig_chart_11 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1
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  • Plasmodium yoelii [ChEMBL: CHEMBL612889]
  • This target only has 0 pki data point
  • 0
12 CHEMBL12089_lig_chart_12 Plasmodium yoelii Plasmodium yoelii
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • This target only has 1 pki data point
  • 5.66
13 CHEMBL12089_lig_chart_13 Serotonin 2b (5-HT2b) receptor Human
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  • Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
  • This target only has 1 pki data point
  • 6.43
14 CHEMBL12089_lig_chart_14 Serotonin 4 (5-HT4) receptor Guinea pig
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • This target only has 1 pki data point
  • 6.27
15 CHEMBL12089_lig_chart_15 Sigma opioid receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL Inhibition of electric eel AChE by enzyme kinetics assay B 6.54 pKi 289 nM Ki Bioorg. Med. Chem. (2010) 18: 1244-1251 [PMID:20056426]
ChEMBL Inhibition of electric eel AChE by Ellman's method B 5.56 pIC50 2740 nM IC50 Bioorg. Med. Chem. (2012) 20: 6669-6679 [PMID:23062825]
ChEMBL Inhibition of electric eel AChE by Ellman's assay B 6.43 pIC50 374 nM IC50 Bioorg. Med. Chem. (2010) 18: 4475-4484 [PMID:20471843]
ChEMBL Inhibition of electric eel AChE after 15 mins by Ellman's method using acetylcholine as substrate B 6.43 pIC50 374 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 6649-6652 [PMID:20880702]
ChEMBL Inhibition of electric eel AChE by modified Ellman method B 6.43 pIC50 374 nM IC50 Bioorg. Med. Chem. (2010) 18: 1244-1251 [PMID:20056426]
ChEMBL Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's method B 6.43 pIC50 374 nM IC50 Bioorg. Med. Chem. (2011) 19: 7228-7235 [PMID:22041172]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's method B 6.43 pIC50 374 nM IC50 Bioorg. Med. Chem. (2013) 21: 5830-5840 [PMID:23932451]
ChEMBL Inhibition of electric eel Acetylcholinesterase B 6.43 pIC50 374 nM IC50 Bioorg. Med. Chem. (2011) 19: 2298-2305 [PMID:21397508]
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) B 6.11 pIC50 774 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of human AChE by Ellman's method B 6.21 pIC50 610 nM IC50 Bioorg. Med. Chem. (2012) 20: 6669-6679 [PMID:23062825]
ChEMBL Inhibition of AChE assessed as hydrolysis of acetylcholine preincubated for 15 mins measured after 15 mins by colorimetric Ellman assay B 7.4 pIC50 40 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6603-6607 [PMID:21924611]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) B 6.56 pKi 274 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) B 6.22 pIC50 601 nM IC50 DrugMatrix in vitro pharmacology data
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) B 6.39 pKi 412 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) B 5.55 pIC50 2837 nM IC50 DrugMatrix in vitro pharmacology data
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of BChE assessed as hydrolysis of butrylcholine preincubated for 15 mins measured after 15 mins by colorimetric Ellman assay B 4.72 pIC50 18970 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6603-6607 [PMID:21924611]
Butyrylcholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9]
ChEMBL Inhibition of equine BChE after 15 mins by Ellman's method using acetylcholine as substrate B 4.74 pIC50 18200 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 6649-6652 [PMID:20880702]
ChEMBL Inhibition of equine serum Butyrylcholinesterase B 4.74 pIC50 18200 nM IC50 Bioorg. Med. Chem. (2011) 19: 2298-2305 [PMID:21397508]
ChEMBL Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method B 4.74 pIC50 18200 nM IC50 Bioorg. Med. Chem. (2011) 19: 7228-7235 [PMID:22041172]
Cell division protein ftsZ in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6]
ChEMBL Displacement of bis-ANS from Escherichia coli FtsZ B 7.64 pKd 23 nM Kd J Med Chem (2016) 59: 6975-6998 [PMID:26756351]
ChEMBL Inhibition of recombinant Escherichia coli K12 FtsZ GTPase activity by malachite green sodium molybdate assay B 4.8 pIC50 16000 nM IC50 Bioorg Med Chem (2016) 24: 6354-6369 [PMID:27189886]
ChEMBL Inhibition of recombinant Escherichia coli K12 FtsZ assembly by light-scattering assay B 5 pIC50 10000 nM IC50 Bioorg Med Chem (2016) 24: 6354-6369 [PMID:27189886]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL Inhibition of horse serum BChE by enzyme kinetics assay B 5.04 pKi 9200 nM Ki Bioorg. Med. Chem. (2010) 18: 1244-1251 [PMID:20056426]
ChEMBL Inhibition of equine serum BChE using butylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's method B 4.74 pIC50 18210 nM IC50 Bioorg. Med. Chem. (2013) 21: 5830-5840 [PMID:23932451]
ChEMBL Inhibition of horse serum BChE by Ellman's method B 4.74 pIC50 18200 nM IC50 Bioorg. Med. Chem. (2010) 18: 1244-1251 [PMID:20056426]
ChEMBL Inhibition of equine serum BuChE by Ellman's method B 4.74 pIC50 18200 nM IC50 Bioorg. Med. Chem. (2010) 18: 4475-4484 [PMID:20471843]
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) B 5.35 pIC50 4504.2 nM IC50 DrugMatrix in vitro pharmacology data
GtoPdb - - 5.4 pIC50 - - - Pharmaceutics (2020) 12: [PMID:32987920]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG by patch clamp assay B 5.51 pIC50 3100 nM IC50 Eur J Med Chem (2017) 140: 448-464 [PMID:28987606]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 6.13 pKi 742 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) B 5.51 pIC50 3080 nM IC50 DrugMatrix in vitro pharmacology data
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay F 6.35 pEC50 442 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay F 6.66 pEC50 218 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antiplasmodial activity against multi drug-resistant Plasmodium falciparum K1 in erythrocytes by [3H]hypoxanthine uptake F 6.01 pIC50 968 nM IC50 J. Nat. Prod. (2000) 63: 1638-1640 [PMID:11141105]
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889]
ChEMBL NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration F 6.26 pIC50 548 nM IC50 Science (2011) 334: 1372-1377 [PMID:22096101]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) B 5.66 pKi 2187 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) B 5.46 pIC50 3437 nM IC50 DrugMatrix in vitro pharmacology data
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) B 6.43 pKi 370 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) B 5.65 pIC50 2222 nM IC50 DrugMatrix in vitro pharmacology data
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) B 6.27 pKi 542 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) B 5.89 pIC50 1289 nM IC50 DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]