ChEMBL ligand: CHEMBL49429 (CRTX 080, CRTX-080, Lixar, Lixivaptan, Vpa-985, VPA 985, VPA-985, WAY-VPA-985)
OT receptor/Oxytocin receptor in Human [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] There should be some charts here, you may need to enable JavaScript!
V1A receptor/Vasopressin V1a receptor in Human [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] V1A receptor/Vasopressin V1a receptor in Rat [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560] There should be some charts here, you may need to enable JavaScript!
V2 receptor/Vasopressin V2 receptor in Human [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] V2 receptor/Vasopressin V2 receptor in Rat [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559]
ChEMBL	Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cells	B	6.28	pIC50	519	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5796-5800 [PMID:17855087]
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
ChEMBL	Inhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptor	B	5.22	pKi	6000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2747-2752 [PMID:15125926]
ChEMBL	Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptor	B	7.36	pKi	44	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2747-2752 [PMID:15125926]
ChEMBL	Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracellular calcium level	F	5.3	pIC50	>5000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6623-6628 [PMID:17942308]
ChEMBL	Displacement of [3H]AVP from vasopressin receptor (V1a) from human platelet membranes.	B	6.64	pIC50	230	nM	IC50	J Med Chem (1998) 41: 2442-2444 [PMID:9651149]
ChEMBL	In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membrane	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1733-1736 [PMID:10406632]
ChEMBL	In vitro binding affinity to human V1a receptor	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (2000) 10: 695-698 [PMID:10782666]
ChEMBL	Inhibitory concentration against [3H]AVP binding to human vasopressin V1a receptor	B	6.74	pIC50	180	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5003-5006 [PMID:16153837]
ChEMBL	Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V1a receptor	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2002) 12: 3081-3084 [PMID:12372506]
ChEMBL	Binding affinity towards human V1a receptors	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2003) 13: 753-756 [PMID:12639574]
ChEMBL	Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cells	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6623-6628 [PMID:17942308]
ChEMBL	Displacement of [3H]manning ligand from human vasopressin V1a receptor expressed in CHO cells	B	6.91	pIC50	124	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5796-5800 [PMID:17855087]
V1A receptor/Vasopressin V1a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560]
ChEMBL	Inhibition of [3H]AVP binding to Dawley rat hepatic vasopressin V1a receptor.	B	6.39	pIC50	410	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2195-2198 [PMID:12798333]
ChEMBL	In vitro binding affinity for rat V1a receptor	B	6.47	pIC50	340	nM	IC50	Bioorg Med Chem Lett (2000) 10: 695-698 [PMID:10782666]
ChEMBL	Displacement of (Phe-3,4,5-H) Vasopressin from V1a receptor from rat liver membranes.	B	6.47	pIC50	340	nM	IC50	J Med Chem (1998) 41: 2442-2444 [PMID:9651149]
ChEMBL	Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor	B	7.09	pIC50	82	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1737-1740 [PMID:10406633]
V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
ChEMBL	Inhibition of AVP mediated activation of human vasopressin V2 receptor expressed in HEK293 cells	B	7.05	pKi	90	nM	Ki	Bioorg Med Chem Lett (2002) 12: 3081-3084 [PMID:12372506]
ChEMBL	Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptor	F	7.64	pKi	23	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2747-2752 [PMID:15125926]
ChEMBL	Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptor	B	8.64	pKi	2.3	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2747-2752 [PMID:15125926]
GtoPdb	-	-	9.2	pKi	-	-	Ki	Kidney Int (2000) 58: 1613-22 [PMID:11012895]; J Med Chem (1998) 41: 2442-4 [PMID:9651149]
ChEMBL	Antagonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levels	F	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6623-6628 [PMID:17942308]
ChEMBL	Inhibitory activity of the human V2 receptor was assessed by the accumulation of cAMP in transfected HEK293 cells.	F	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2003) 13: 753-756 [PMID:12639574]
ChEMBL	Inhibition of [3H]Arg-vasopressin binding to recombinant human vasopressin V2 receptor	B	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (2002) 12: 3081-3084 [PMID:12372506]
ChEMBL	Inhibitory activity of the human V2 receptor was assessed by the accumulation of cAMP in transfected HEK293 cells.	F	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (2003) 13: 753-756 [PMID:12639574]
ChEMBL	Displacement of [3H]Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cells	B	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6623-6628 [PMID:17942308]
ChEMBL	In vitro inhibition of [3H]AVP binding to human V2 receptor from murine fibroblast cell line (LV2)	B	8.92	pIC50	1.2	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1733-1736 [PMID:10406632]
ChEMBL	Displacement of [3H]AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranes	B	8.92	pIC50	1.2	nM	IC50	Bioorg Med Chem Lett (2000) 10: 783-786 [PMID:10782686]
ChEMBL	In vitro binding affinity to human V2 receptor	B	8.92	pIC50	1.2	nM	IC50	Bioorg Med Chem Lett (2000) 10: 695-698 [PMID:10782666]
ChEMBL	Displacement of [3H]AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranes	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (1998) 41: 2442-2444 [PMID:9651149]
ChEMBL	Displacement of [3H]AVP from human vasopressin V2 receptor expressed in mouse LV2 cells	B	8.92	pIC50	1.2	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5796-5800 [PMID:17855087]
ChEMBL	Inhibition of [3H]-AVP binding to human V2 receptor	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2005) 15: 5003-5006 [PMID:16153837]
V2 receptor/Vasopressin V2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788]
ChEMBL	Binding affinity to rat V2 receptor	B	8.64	pIC50	2.3	nM	IC50	Bioorg Med Chem Lett (2000) 10: 695-698 [PMID:10782666]
ChEMBL	Inhibition of [3H]AVP binding to Dawley rat kidney medullary vasopressin V2 receptor.	B	8.64	pIC50	2.3	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2195-2198 [PMID:12798333]
ChEMBL	Displacement of [3H]AVP from vasopressin V2 receptor of rat kidney medulla.	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (1998) 41: 2442-2444 [PMID:9651149]
ChEMBL	Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor	B	9.3	pIC50	0.5	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1737-1740 [PMID:10406633]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]