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ChEMBL ligand: CHEMBL566515 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709] | ||||||||
ChEMBL | Inhibition of EphA1 by [gamma33-P]ATP based assay | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
GtoPdb | - | - | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] | ||||||||
ChEMBL | Inhibition of EphA2 by [gamma33-P]ATP based assay | B | 8.64 | pIC50 | 2.3 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
GtoPdb | - | - | 8.64 | pIC50 | 2.3 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320] | ||||||||
ChEMBL | Inhibition of EphA3 by [gamma33-P]ATP based assay | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
GtoPdb | - | - | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764] | ||||||||
GtoPdb | - | - | 8.48 | pIC50 | 3.3 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
ChEMBL | Inhibition of EphA4 by [gamma33-P]ATP based assay | B | 8.48 | pIC50 | 3.3 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756] | ||||||||
GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
ChEMBL | Inhibition of EphA5 by [gamma33-P]ATP based assay | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375] | ||||||||
GtoPdb | - | - | 5.95 | pIC50 | 1118 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
ChEMBL | Inhibition of EphA7 by [gamma33-P]ATP based assay | B | 5.95 | pIC50 | 1118 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322] | ||||||||
ChEMBL | Inhibition of EphA8 by [gamma33-P]ATP based assay | B | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
GtoPdb | - | - | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762] | ||||||||
ChEMBL | Inhibition of EphB1 by [gamma33-P]ATP based assay | B | 8.96 | pIC50 | 1.1 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
GtoPdb | - | - | 8.96 | pIC50 | 1.1 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
GtoPdb | - | - | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
ChEMBL | Inhibition of EphB2 by [gamma33-P]ATP based assay | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753] | ||||||||
GtoPdb | - | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
ChEMBL | Inhibition of EphB3 by [gamma33-P]ATP based assay | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] | ||||||||
ChEMBL | Inhibition of human myc-tagged full length EphB4 expressed in MEF cells assessed as inhibition of ephrinB2-Fc-induced autophosphorylation incubated for 90 mins prior to ephrinB2-Fc-induction measured after 2 hrs by sandwich ELISA | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2013) 56: 84-96 [PMID:23253074] |
ChEMBL | Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
ChEMBL | Inhibition of EphB4 (unknown origin) using Z'-LYTE TYR-1 peptide as substrate after 2 hrs by FRET assay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2013) 56: 84-96 [PMID:23253074] |
ChEMBL | Inhibition of EphB4 by [gamma33-P]ATP based assay | B | 8.8 | pIC50 | 1.6 | nM | IC50 | J Med Chem (2009) 52: 6433-6446 [PMID:19788238] |
ChEMBL | Inhibition of EphB4 (unknown origin) using [gamma-33P]ATP by radiometric assay | B | 8.8 | pIC50 | 1.6 | nM | IC50 | J Med Chem (2013) 56: 84-96 [PMID:23253074] |
GtoPdb | - | - | 8.8 | pIC50 | 1.6 | nM | IC50 | J Med Chem (2009) 52: 6433-46 [PMID:19788238] |
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of Abl (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay | B | 9.04 | pIC50 | 0.92 | nM | IC50 | J Med Chem (2013) 56: 84-96 [PMID:23253074] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of Lck (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay | B | 8.89 | pIC50 | 1.3 | nM | IC50 | J Med Chem (2013) 56: 84-96 [PMID:23253074] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
ChEMBL | Inhibition of Src (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay | B | 8.94 | pIC50 | 1.14 | nM | IC50 | J Med Chem (2013) 56: 84-96 [PMID:23253074] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]