ChEMBL ligand: CHEMBL566515
EPH receptor A1/Ephrin type-A receptor 1 in Human [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709] There should be some charts here, you may need to enable JavaScript!
EPH receptor A2/Ephrin type-A receptor 2 in Human [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] There should be some charts here, you may need to enable JavaScript!
EPH receptor A3/Ephrin type-A receptor 3 in Human [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320] There should be some charts here, you may need to enable JavaScript!
EPH receptor A4/Ephrin type-A receptor 4 in Human [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764] There should be some charts here, you may need to enable JavaScript!
EPH receptor A5/Ephrin type-A receptor 5 in Human [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756] There should be some charts here, you may need to enable JavaScript!
EPH receptor A7/Ephrin type-A receptor 7 in Human [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375] There should be some charts here, you may need to enable JavaScript!
EPH receptor A8/Ephrin type-A receptor 8 in Human [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322] There should be some charts here, you may need to enable JavaScript!
EPH receptor B1/Ephrin type-B receptor 1 in Human [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762] There should be some charts here, you may need to enable JavaScript!
EPH receptor B2/Ephrin type-B receptor 2 in Human [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] There should be some charts here, you may need to enable JavaScript!
EPH receptor B3/Ephrin type-B receptor 3 in Human [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753] There should be some charts here, you may need to enable JavaScript!
EPH receptor B4/Ephrin type-B receptor 4 in Human [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] There should be some charts here, you may need to enable JavaScript!
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709]
ChEMBL	Inhibition of EphA1 by [gamma33-P]ATP based assay	B	8.54	pIC50	2.9	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
GtoPdb	-	-	8.54	pIC50	2.9	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
ChEMBL	Inhibition of EphA2 by [gamma33-P]ATP based assay	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
GtoPdb	-	-	8.64	pIC50	2.3	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320]
ChEMBL	Inhibition of EphA3 by [gamma33-P]ATP based assay	B	7.4	pIC50	40	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
GtoPdb	-	-	7.4	pIC50	40	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764]
GtoPdb	-	-	8.48	pIC50	3.3	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
ChEMBL	Inhibition of EphA4 by [gamma33-P]ATP based assay	B	8.48	pIC50	3.3	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756]
GtoPdb	-	-	8.52	pIC50	3	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
ChEMBL	Inhibition of EphA5 by [gamma33-P]ATP based assay	B	8.52	pIC50	3	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375]
GtoPdb	-	-	5.95	pIC50	1118	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
ChEMBL	Inhibition of EphA7 by [gamma33-P]ATP based assay	B	5.95	pIC50	1118	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322]
ChEMBL	Inhibition of EphA8 by [gamma33-P]ATP based assay	B	8.35	pIC50	4.5	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
GtoPdb	-	-	8.35	pIC50	4.5	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
ChEMBL	Inhibition of EphB1 by [gamma33-P]ATP based assay	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
GtoPdb	-	-	8.96	pIC50	1.1	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
GtoPdb	-	-	8.92	pIC50	1.2	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
ChEMBL	Inhibition of EphB2 by [gamma33-P]ATP based assay	B	8.92	pIC50	1.2	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753]
GtoPdb	-	-	7.82	pIC50	15	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
ChEMBL	Inhibition of EphB3 by [gamma33-P]ATP based assay	B	7.82	pIC50	15	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760]
ChEMBL	Inhibition of human myc-tagged full length EphB4 expressed in MEF cells assessed as inhibition of ephrinB2-Fc-induced autophosphorylation incubated for 90 mins prior to ephrinB2-Fc-induction measured after 2 hrs by sandwich ELISA	B	6.89	pIC50	130	nM	IC50	J Med Chem (2013) 56: 84-96 [PMID:23253074]
ChEMBL	Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay	B	8.3	pIC50	5	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
ChEMBL	Inhibition of EphB4 (unknown origin) using Z'-LYTE TYR-1 peptide as substrate after 2 hrs by FRET assay	B	8.3	pIC50	5	nM	IC50	J Med Chem (2013) 56: 84-96 [PMID:23253074]
ChEMBL	Inhibition of EphB4 by [gamma33-P]ATP based assay	B	8.8	pIC50	1.6	nM	IC50	J Med Chem (2009) 52: 6433-6446 [PMID:19788238]
ChEMBL	Inhibition of EphB4 (unknown origin) using [gamma-33P]ATP by radiometric assay	B	8.8	pIC50	1.6	nM	IC50	J Med Chem (2013) 56: 84-96 [PMID:23253074]
GtoPdb	-	-	8.8	pIC50	1.6	nM	IC50	J Med Chem (2009) 52: 6433-46 [PMID:19788238]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Inhibition of Abl (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay	B	9.04	pIC50	0.92	nM	IC50	J Med Chem (2013) 56: 84-96 [PMID:23253074]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL	Inhibition of Lck (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (2013) 56: 84-96 [PMID:23253074]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of Src (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay	B	8.94	pIC50	1.14	nM	IC50	J Med Chem (2013) 56: 84-96 [PMID:23253074]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]