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ChEMBL ligand: CHEMBL463 (Aminohippuric acid, Aminohippuric Acid, Aminohippuric acid, p-, NSC-13064, Paha, P-aminohippuric acid, Para-aminohippurate, Para-aminohippuric acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8] | ||||||||
ChEMBL | Inhibition of human Oat1 expressed in Drosophila S2 cells | B | 5.22 | pKi | 6020 | nM | Ki | Bioorg Med Chem (2011) 19: 3320-3340 [PMID:21571536] |
ChEMBL | TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT1-expressing S2 cells | F | 5.22 | pKi | 6020 | nM | Ki | Life Sci (2001) 69: 2123-2135 [PMID:11669456] |
ChEMBL | TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells | F | 5.06 | pIC50 | 8800 | nM | IC50 | Anal Biochem (2000) 283: 49-55 [PMID:10929807] |
Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69] | ||||||||
ChEMBL | Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr | B | 5.03 | pKi | 9400 | nM | Ki | J Biol Chem (2007) 282: 23841-23853 [PMID:17553798] |
ChEMBL | Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr | B | 5.03 | pKi | 9332.54 | nM | Ki | J Biol Chem (2007) 282: 23841-23853 [PMID:17553798] |
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells | F | 4.71 | pKi | 19600 | nM | Ki | Life Sci (2001) 69: 2123-2135 [PMID:11669456] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]