ribavirin [Ligand Id: 6842] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1643 (Copegus, Cotronak, NSC-163039, Rebetol, Ribapak, Ribasphere, Ribavarin, Ribavirin, Ribavirina, Ribavirin biopartners, Ribavirine, Ribavirin mylan, Ribavirin mylan (previously ribavirin three rivers), Ribavirin teva, Ribavirin teva pharma b.v., Ribofluranosyl carboxamide, SCH 18908, SCH-18908, Tribavirin, Viramid, Virazid, Virazole)
  • A1 receptor/Adenosine receptor A1 in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
  • A1 receptor/Adenosine receptor A1 in Mouse [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612]
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  • DNA topoisomerase I/DNA topoisomerase 1 in Human [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
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  • Eukaryotic translation initiation factor 4E in Human [ChEMBL: CHEMBL4848] [UniProtKB: P06730]
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  • inosine monophosphate dehydrogenase 1 in Human [GtoPdb: 2624] [UniProtKB: P20839]
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  • inosine monophosphate dehydrogenase 2 in Human [GtoPdb: 2625] [UniProtKB: P12268]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine receptor A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay B 5.13 pKi 7410 nM Ki J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
A1 receptor/Adenosine receptor A1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612]
ChEMBL Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay B 5.35 pKi 4430 nM Ki J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
DNA topoisomerase I/DNA topoisomerase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL Inhibition of human topoisomerase 1 activity assessed as DNA triplex formation and presence of supercoiled DNA by microplate assay B 4.18 pIC50 65880 nM IC50 Medchemcomm (2013) 4: 278-288
Eukaryotic translation initiation factor 4E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4848] [UniProtKB: P06730]
ChEMBL Binding affinity to eIF4E (unknown origin) assessed as dissociation constant B 5.08 pKd 8400 nM Kd RSC Med Chem (2023) 14: 1060-1087 [PMID:37360400]
Genome polyprotein in Enterovirus A71 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295606] [UniProtKB: Q66478]
ChEMBL Inhibition of Enterovirus 71 Shenzhen/120F1/09 capsid infected in human RD cells assessed as reduction in virus-induced cell death after 72 hrs by CCK-8 assay B 4 pEC50 >100000 nM EC50 ACS Med Chem Lett (2017) 8: 841-846 [PMID:28835799]
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity after 72 hrs by DAPI staining based assay B 4.68 pEC50 20800 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
RNA-directed RNA polymerase in Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4523676] [UniProtKB: P03428, P03431, P03433]
ChEMBL Inhibition of RdRP activity in Influenza A virus A/PR/8/34 (H1N1) infected in HEK293T cells co-transfected with NP/PA/PB1/PB2/pPolI-Flu-ffLuc/pRL-SV40 incubated for 24 hrs by minireplicon based dual luciferase assay B 4.62 pEC50 24000 nM EC50 Eur J Med Chem (2021) 209: 112944-112944 [PMID:33328103]
ChEMBL Inhibition of Influenza A virus RdRp transfected in HEK293T cells co-expressing PA/PB1/PB2/NP/firefly luciferase/Renilla luciferase assessed as impaired nuclear import preincubated for 4 hrs followed by medium replacement with compound measured after 20 hrs by minireplicon assay B 4.66 pEC50 21700 nM EC50 Eur J Med Chem (2024) 277: 116737-116737 [PMID:39153334]
ChEMBL Inhibition of RdRP activity in Influenza A virus A/PR/8/34(H1N1) infected in HEK293T cells incubated for 24 hrs by minireplicon based dual luciferase assay B 4.8 pEC50 16000 nM EC50 Eur J Med Chem (2021) 221: 113494-113494 [PMID:33962311]
inosine monophosphate dehydrogenase 1 in Human [GtoPdb: 2624] [UniProtKB: P20839]
GtoPdb In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed) - 6 pIC50 1000 nM IC50 Bioorg Med Chem (2012) 20: 3675-85 [PMID:22555152]
inosine monophosphate dehydrogenase 2 in Human [GtoPdb: 2625] [UniProtKB: P12268]
GtoPdb In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed) - 6 pIC50 1000 nM IC50 Bioorg Med Chem (2012) 20: 3675-85 [PMID:22555152]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]