ribavirin [Ligand Id: 6842] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1643 (Ribavirin, Ribapak, Tribavirin, SCH-18908, Viramid, Rebetol, Ribasphere, Ribavarin, Ribofluranosyl Carboxamide, Virazid, NSC-163039, Copegus, Virazole, SCH 18908)
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
  • A1 receptor/Adenosine A1 receptor in Mouse [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612]
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  • Genome polyprotein in Human enterovirus 71 (strain BrCr) (Ev 71) [ChEMBL: CHEMBL4295606] [UniProtKB: Q66478]
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  • inosine monophosphate dehydrogenase 1 in Human [GtoPdb: 2624] [UniProtKB: P20839]
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  • inosine monophosphate dehydrogenase 2 in Human [GtoPdb: 2625] [UniProtKB: P12268]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay B 5.13 pKi 7410 nM Ki J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
A1 receptor/Adenosine A1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612]
ChEMBL Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay B 5.35 pKi 4430 nM Ki J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL Inhibition of human topoisomerase 1 activity assessed as DNA triplex formation and presence of supercoiled DNA by microplate assay B 4.18 pIC50 65880 nM IC50 MedChemComm (2013) 4: 278-288
Genome polyprotein in Human enterovirus 71 (strain BrCr) (Ev 71) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295606] [UniProtKB: Q66478]
ChEMBL Inhibition of Enterovirus 71 Shenzhen/120F1/09 capsid infected in human RD cells assessed as reduction in virus-induced cell death after 72 hrs by CCK-8 assay B 4 pEC50 >100000 nM EC50 ACS Med Chem Lett (2017) 8: 841-846 [PMID:28835799]
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity after 72 hrs by DAPI staining based assay B 4.68 pEC50 20800 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
inosine monophosphate dehydrogenase 1 in Human [GtoPdb: 2624] [UniProtKB: P20839]
GtoPdb In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed) - 6 pIC50 1000 nM IC50 Bioorg Med Chem (2012) 20: 3675-85 [PMID:22555152]
inosine monophosphate dehydrogenase 2 in Human [GtoPdb: 2625] [UniProtKB: P12268]
GtoPdb In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed) - 6 pIC50 1000 nM IC50 Bioorg Med Chem (2012) 20: 3675-85 [PMID:22555152]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]