zidesamtinib [Ligand Id: 12392] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| GtoPdb | Inhibitin of WT TRKA | - | 7.3 | pKi | 50 | nM | Ki | US11542278. Heteroaromatic macrocyclic ether chemotherapeutic agents (2023) |
| c-ros oncogene 1, receptor tyrosine kinase in Human [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
| GtoPdb | Inhibition of ROS1G2032R | - | 7.3 | pKi | <50 | nM | Ki | US11542278. Heteroaromatic macrocyclic ether chemotherapeutic agents (2023) |
| GtoPdb | Inhibition of wild-type ROS1 in an enzyme activity assay | - | 9.15 | pIC50 | 0.7 | nM | IC50 | Cancer Discov (2023) 13: 598-615 [PMID:36511802] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
