ChEMBL ligand: CHEMBL1046 (177 J.D, 177 J.D., 177 JD, 177-JD, 6-aminocaproic acid, Amicar, Aminocaproic, Aminocaproic acid, CL 10304, CL-10304, CY-116, EACA, Epsikapron, Epsilcapramin, .epsilon.-aminocaproic acid, Epsilon-aminocaproic acid, Hexanoic acid, 6-amino-, NSC-26154, NSC-400230)
plasminogen/Plasminogen in Human [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] There should be some charts here, you may need to enable JavaScript!
Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL	Binding affinity to human plasminogen K1 domain by ultrafiltration technique	B	5.05	pKd	9000	nM	Kd	J Med Chem (2020) 63: 1445-1472 [PMID:31658420]
ChEMBL	Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA	B	4.4	pIC50	40000	nM	IC50	ACS Med Chem Lett (2014) 5: 538-543 [PMID:24900876]
GtoPdb	Measuring inhibition of fibrinolysis in plasma.	-	4.4	pIC50	40000	nM	IC50	ACS Med Chem Lett (2014) 5: 538-543 [PMID:24900876]
Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8]
ChEMBL	Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting	B	1.54	pKi	-1.54	mM	pKi	Bioorg Med Chem (2011) 19: 6409-6418 [PMID:21955456]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]