6-aminocaproic acid [Ligand Id: 6574] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1046 (177 JD, 177 J.D, 177 J.D., 177-JD, 6-aminocaproic acid, Amicar, Aminocaproic, Aminocaproic acid, CL 10304, CL-10304, CY-116, EACA, Epsikapron, Epsilcapramin, .epsilon.-aminocaproic acid, Epsilon-aminocaproic acid, Hexanoic acid, 6-amino-, NSC-26154, NSC-400230)
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  • Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL Binding affinity to human plasminogen K1 domain by ultrafiltration technique B 5.05 pKd 9000 nM Kd J Med Chem (2020) 63: 1445-1472 [PMID:31658420]
ChEMBL Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA B 4.4 pIC50 40000 nM IC50 ACS Med. Chem. Lett. (2014) 5: 538-543 [PMID:24900876]
GtoPdb Measuring inhibition of fibrinolysis in plasma. - 4.4 pIC50 40000 nM IC50 ACS Med Chem Lett (2014) 5: 538-543 [PMID:24900876]
Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8]
ChEMBL Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting B 1.54 pKi -1.54 mM pKi Bioorg. Med. Chem. (2011) 19: 6409-6418 [PMID:21955456]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]