vinpocetine [Ligand Id: 5285] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL71752 (Vinpocetine, AY-27255, Cavinton)
  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 0 pki data point
1 CHEMBL71752_lig_chart_1 HERG Human
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  • phosphodiesterase 10A/Phosphodiesterase 10A in Human [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
  • This target only has 0 pki data point
2 CHEMBL71752_lig_chart_2 Phosphodiesterase 10A Human
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  • phosphodiesterase 1B/Phosphodiesterase 1B in Human [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064]
  • This target only has 0 pki data point
3 CHEMBL71752_lig_chart_3 Phosphodiesterase 1B Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
4 CHEMBL71752_lig_chart_4 Plasmodium falciparum Plasmodium falciparum
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  • phosphodiesterase 1A in Human [GtoPdb: 1294] [UniProtKB: P54750]
  • This target only has 0 pki data point
5 CHEMBL71752_lig_chart_5 phosphodiesterase 1A Human
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  • phosphodiesterase 1C in Human [GtoPdb: 1296] [UniProtKB: Q14123]
  • This target only has 0 pki data point
6 CHEMBL71752_lig_chart_6 phosphodiesterase 1C Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 7.41 pIC50 39 nM IC50 J Med Chem (2017) 60: 3472-3483 [PMID:28406621]
phosphodiesterase 10A/Phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
ChEMBL Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assay B 5 pIC50 >10000 nM IC50 J Med Chem (2017) 60: 3472-3483 [PMID:28406621]
phosphodiesterase 1B/Phosphodiesterase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064]
ChEMBL Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured after 30 mins by IMAP assay B 5 pIC50 >10000 nM IC50 J Med Chem (2017) 60: 3472-3483 [PMID:28406621]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 5.1 pIC50 7943.28 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
phosphodiesterase 1A in Human [GtoPdb: 1294] [UniProtKB: P54750]
GtoPdb - - 5.1 pIC50 7940 nM IC50 J. Biol. Chem. (1996) 271: 796-806 [PMID:8557689]
phosphodiesterase 1C in Human [GtoPdb: 1296] [UniProtKB: Q14123]
GtoPdb - - 4.3 pIC50 50100 nM IC50 J. Biol. Chem. (1996) 271: 796-806 [PMID:8557689]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]