ChEMBL ligand: CHEMBL71752 (Vinpocetine, AY-27255, Cavinton)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] This target only has 0 pki data point 1 CHEMBL71752_lig_chart_1 HERG Human There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 10A/Phosphodiesterase 10A in Human [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233] This target only has 0 pki data point 2 CHEMBL71752_lig_chart_2 Phosphodiesterase 10A Human There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 1B/Phosphodiesterase 1B in Human [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064] This target only has 0 pki data point 3 CHEMBL71752_lig_chart_3 Phosphodiesterase 1B Human There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] This target only has 0 pki data point 4 CHEMBL71752_lig_chart_4 Plasmodium falciparum Plasmodium falciparum There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 1A in Human [GtoPdb: 1294] [UniProtKB: P54750] This target only has 0 pki data point 5 CHEMBL71752_lig_chart_5 phosphodiesterase 1A Human There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 1C in Human [GtoPdb: 1296] [UniProtKB: Q14123] This target only has 0 pki data point 6 CHEMBL71752_lig_chart_6 phosphodiesterase 1C Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG	B	7.41	pIC50	39	nM	IC50	J Med Chem (2017) 60: 3472-3483 [PMID:28406621]
phosphodiesterase 10A/Phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
ChEMBL	Inhibition of PDE10A1 (unknown origin) assessed as decrease in FAM-cAMP hydrolysis after 1 hr by IMAP assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2017) 60: 3472-3483 [PMID:28406621]
phosphodiesterase 1B/Phosphodiesterase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4425] [GtoPdb: 1295] [UniProtKB: Q01064]
ChEMBL	Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP addition measured after 30 mins by IMAP assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2017) 60: 3472-3483 [PMID:28406621]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
phosphodiesterase 1A in Human [GtoPdb: 1294] [UniProtKB: P54750]
GtoPdb	-	-	5.1	pIC50	7940	nM	IC50	J. Biol. Chem. (1996) 271: 796-806 [PMID:8557689]
phosphodiesterase 1C in Human [GtoPdb: 1296] [UniProtKB: Q14123]
GtoPdb	-	-	4.3	pIC50	50100	nM	IC50	J. Biol. Chem. (1996) 271: 796-806 [PMID:8557689]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]