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ChEMBL ligand: CHEMBL259352 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Transcriptional activator protein lasR in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075207] [UniProtKB: P25084] | ||||||||
ChEMBL | Antagonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in presence of 7.5 nM natural auto-inducer 3-oxo-C12-HSL | F | 5.76 | pIC50 | 1750 | nM | IC50 | J Med Chem (2010) 53: 7467-7489 [PMID:20669927] |
ChEMBL | Antagonist activity at Pseudomonas aeruginosa LasR expressed in Escherichia coli DH5alpha assessed as inhibition of protein interaction with OdDHL after 1.5 hrs by beta-galactosidase reporter gene assay | B | 6.47 | pIC50 | 340 | nM | IC50 | J Med Chem (2018) 61: 10385-10402 [PMID:29999316] |
Transcriptional activator protein luxR in Aliivibrio fischeri (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5351] [UniProtKB: P12746] | ||||||||
ChEMBL | Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSL | F | 6.11 | pIC50 | 770 | nM | IC50 | J Med Chem (2010) 53: 7467-7489 [PMID:20669927] |
Transcriptional activator protein traR in Agrobacterium tumefaciens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5865] [UniProtKB: P33905] | ||||||||
ChEMBL | Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSL | F | 6.11 | pIC50 | 770 | nM | IC50 | J Med Chem (2010) 53: 7467-7489 [PMID:20669927] |
TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8] | ||||||||
GtoPdb | - | - | 4.71 | pEC50 | 19650 | nM | EC50 | ACS Infect Dis (2018) 4: 1146-1156 [PMID:29799189] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]