ChEMBL ligand: CHEMBL259352
Transcriptional activator protein lasR in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL1075207] [UniProtKB: P25084] There should be some charts here, you may need to enable JavaScript!
Transcriptional activator protein luxR in Aliivibrio fischeri [ChEMBL: CHEMBL5351] [UniProtKB: P12746] There should be some charts here, you may need to enable JavaScript!
Transcriptional activator protein traR in Agrobacterium tumefaciens [ChEMBL: CHEMBL5865] [UniProtKB: P33905] There should be some charts here, you may need to enable JavaScript!
TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Transcriptional activator protein lasR in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075207] [UniProtKB: P25084]
ChEMBL	Antagonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in presence of 7.5 nM natural auto-inducer 3-oxo-C12-HSL	F	5.76	pIC50	1750	nM	IC50	J Med Chem (2010) 53: 7467-7489 [PMID:20669927]
ChEMBL	Antagonist activity at Pseudomonas aeruginosa LasR expressed in Escherichia coli DH5alpha assessed as inhibition of protein interaction with OdDHL after 1.5 hrs by beta-galactosidase reporter gene assay	B	6.47	pIC50	340	nM	IC50	J Med Chem (2018) 61: 10385-10402 [PMID:29999316]
Transcriptional activator protein luxR in Aliivibrio fischeri (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5351] [UniProtKB: P12746]
ChEMBL	Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSL	F	6.11	pIC50	770	nM	IC50	J Med Chem (2010) 53: 7467-7489 [PMID:20669927]
Transcriptional activator protein traR in Agrobacterium tumefaciens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5865] [UniProtKB: P33905]
ChEMBL	Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSL	F	6.11	pIC50	770	nM	IC50	J Med Chem (2010) 53: 7467-7489 [PMID:20669927]
TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8]
GtoPdb	-	-	4.71	pEC50	19650	nM	EC50	ACS Infect Dis (2018) 4: 1146-1156 [PMID:29799189]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]