N-octanoyl-L-homoserine lactone [Ligand Id: 12447] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL259352
  • Transcriptional activator protein lasR in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL1075207] [UniProtKB: P25084]
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  • Transcriptional activator protein luxR in Aliivibrio fischeri [ChEMBL: CHEMBL5351] [UniProtKB: P12746]
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  • Transcriptional activator protein traR in Agrobacterium tumefaciens [ChEMBL: CHEMBL5865] [UniProtKB: P33905]
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  • TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Transcriptional activator protein lasR in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075207] [UniProtKB: P25084]
ChEMBL Antagonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in presence of 7.5 nM natural auto-inducer 3-oxo-C12-HSL F 5.76 pIC50 1750 nM IC50 J Med Chem (2010) 53: 7467-7489 [PMID:20669927]
ChEMBL Antagonist activity at Pseudomonas aeruginosa LasR expressed in Escherichia coli DH5alpha assessed as inhibition of protein interaction with OdDHL after 1.5 hrs by beta-galactosidase reporter gene assay B 6.47 pIC50 340 nM IC50 J Med Chem (2018) 61: 10385-10402 [PMID:29999316]
Transcriptional activator protein luxR in Aliivibrio fischeri (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5351] [UniProtKB: P12746]
ChEMBL Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSL F 6.11 pIC50 770 nM IC50 J Med Chem (2010) 53: 7467-7489 [PMID:20669927]
Transcriptional activator protein traR in Agrobacterium tumefaciens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5865] [UniProtKB: P33905]
ChEMBL Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSL F 6.11 pIC50 770 nM IC50 J Med Chem (2010) 53: 7467-7489 [PMID:20669927]
TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8]
GtoPdb - - 4.71 pEC50 19650 nM EC50 ACS Infect Dis (2018) 4: 1146-1156 [PMID:29799189]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]