reboxetine [Ligand Id: 4808] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL180101 (Esreboxetine, REBOXETINE, (s,s)-reboxetine, S,s-reboxetine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Displacement of [3H]WIN35428 from human recombinant DAT transfected in HEK293 cell membrane | B | 4.7 | pKi | 19952.62 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 1456-1461 [PMID:23347683] |
| ChEMBL | Displacement of [125I]RTI-55 from human DAT receptor expressed in canine kidney cells | B | 5.7 | pKi | >2000 | nM | Ki | J Med Chem (2009) 52: 62-73 [PMID:19067522] |
| ChEMBL | Inhibition of dopamine uptake at human DAT expressed in HEK293 cells | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4491-4494 [PMID:18672364] |
| DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
| ChEMBL | Inhibition of dopamine uptake at cloned DAT in rat brain synaptosome | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3682-3686 [PMID:18539031] |
| NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| GtoPdb | - | - | 8 | pKi | 10 | nM | Ki | Biol Psychiatry (2000) 47: 818-29 [PMID:10812041] |
| ChEMBL | Displacement of [3H]nisoxetine from human NET receptor expressed in HEK293 cells | B | 8.98 | pKi | 1.04 | nM | Ki | J Med Chem (2009) 52: 62-73 [PMID:19067522] |
| ChEMBL | Inhibition of norepinephrine reuptake at NET | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem (2009) 17: 7802-7815 [PMID:19836247] |
| ChEMBL | Inhibition of [3H]norepinephrine uptake at human NET expressed in MDCK-Net6 cells by scintillation counting | B | 8.51 | pIC50 | 3.1 | nM | IC50 | J Med Chem (2009) 52: 5703-5711 [PMID:19722525] |
| ChEMBL | Inhibition of norepinephrine uptake at human NET expressed in HEK293 cells | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4491-4494 [PMID:18672364] |
| ChEMBL | Inhibition of human recombinant NET expressed in HEK293 cells assessed as inhibition of [3H]NE reuptake | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1456-1461 [PMID:23347683] |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| ChEMBL | Displacement of [3H]citalopram from human SERT receptor expressed in HEK293 cells | B | 6.18 | pKi | 661 | nM | Ki | J Med Chem (2009) 52: 62-73 [PMID:19067522] |
| ChEMBL | Inhibition of serotonin uptake at human SERT expressed in HEK293 cells | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4491-4494 [PMID:18672364] |
| ChEMBL | Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptake | B | 5.5 | pIC50 | 3162.28 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1456-1461 [PMID:23347683] |
| SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
| ChEMBL | Inhibition of serotonin uptake at SERT in rat brain synaptosome | B | 5.28 | pIC50 | 5200 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3682-3686 [PMID:18539031] |
| Transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6184] [UniProtKB: Q63380] | ||||||||
| ChEMBL | Inhibition of norepinephrine uptake at NET in rat brain synaptosome | B | 8.51 | pIC50 | 3.1 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3682-3686 [PMID:18539031] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
