compound 83 [PMID: 23888932] [Ligand Id: 9742] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2425821
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis B 9.23 pKi 0.59 nM Ki J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
GtoPdb In a radioligand competition binding assay using membranes prepared from CHO cells recombinantly expressing human GPR35. - 9.23 pKi 0.59 nM Ki J Med Chem (2013) 56: 7084-99 [PMID:23888932]
ChEMBL Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay B 8.26 pEC50 5.54 nM EC50 J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]