TL12-186   Click here for help

GtoPdb Ligand ID: 12147

Synonyms: TL 12-186
Compound class: Synthetic organic
Comment: TL12-186 is a PROTAC class molecule, that targets cyclin-dependent kinase (CDK) family proteins for ubiquitination and proteasomal degradation [1]. TL12-186 binds to the CDKs via the parental multi-kinase inhibitor NVP-TAE684 (TAE-684), and uses a pomalidomide moiety to engage cereblon (CRBN). In engineered cell lines expressing individual CDKs, all 16 kinases were degraded by TL12-186 [2]. Interestingly, cell cycle-associated CDKs 1, 2, 4, and 6 were less susceptible to TL12-186-promoted degradation than the other CDKs. Formation of the ternary complex of TL12-186 with CRBN is required for efficient CDK2 degradation.
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Ligand Activity Visualisation Charts

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 19
Hydrogen bond donors 5
Rotatable bonds 21
Topological polar surface area 241.98
Molecular weight 930.32
XLogP 3.72
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C(CNc1cccc2c1C(=O)N(C2=O)C1CCC(=O)NC1=O)NCCOCCOCCN1CCN(CC1)c1ccc(cc1)Nc1ncc(c(n1)Nc1ccccc1S(=O)(=O)C(C)C)Cl
Isomeric SMILES O=C1C(CCC(=O)N1)N1C(=O)c2c(C1=O)cccc2NCC(=O)NCCOCCOCCN1CCN(CC1)c1ccc(cc1)Nc1nc(Nc2c(cccc2)S(=O)(=O)C(C)C)c(cn1)Cl
InChI InChI=1S/C44H51ClN10O9S/c1-28(2)65(61,62)36-9-4-3-7-33(36)50-40-32(45)26-48-44(52-40)49-29-10-12-30(13-11-29)54-19-17-53(18-20-54)21-23-64-25-24-63-22-16-46-38(57)27-47-34-8-5-6-31-39(34)43(60)55(42(31)59)35-14-15-37(56)51-41(35)58/h3-13,26,28,35,47H,14-25,27H2,1-2H3,(H,46,57)(H,51,56,58)(H2,48,49,50,52)
InChI Key YNGWQHGVASHCBK-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
IUPAC Name Click here for help
N-[2-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]piperazin-1-yl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetamide
Synonyms Click here for help
TL 12-186
Database Links Click here for help
CAS Registry No. 2250025-88-6 (source: PubChem)
GtoPdb PubChem SID 472319269
PubChem CID 134812843
Search Google for chemical match using the InChIKey YNGWQHGVASHCBK-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YNGWQHGVASHCBK
UniChem Compound Search for chemical match using the InChIKey YNGWQHGVASHCBK-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey YNGWQHGVASHCBK-UHFFFAOYSA-N