epicatechin gallate [Ligand Id: 12462] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL36327 ((-)-Epicatechin Gallate, Epicatechin Gallate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6] | ||||||||
| ChEMBL | Inhibition of FabG | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| 6-phosphogluconate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3404] [UniProtKB: P52209] | ||||||||
| ChEMBL | Inhibition of 6PGD | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem (2008) 16: 3580-3586 [PMID:18313308] |
| Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluorescence assay | B | 5.01 | pIC50 | 9800 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415] | ||||||||
| ChEMBL | Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay | B | 6.4 | pKi | 400 | nM | Ki | Med Chem Res (2010) 19: 817-835 |
| ChEMBL | Binding affinity to BCL2 | B | 6.64 | pKi | 229.09 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 19512-19517 [PMID:18040043] |
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Displacement of [3H]-CP55940 from CB1 receptor (unknown origin) | B | 4.33 | pKi | 47300 | nM | Ki | J Nat Prod (2019) 82: 636-646 [PMID:30816712] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Displacement of [3H]-CP55940 from CB2 receptor (unknown origin) | B | 4.02 | pKi | 95600 | nM | Ki | J Nat Prod (2019) 82: 636-646 [PMID:30816712] |
| DNA repair protein RAD52 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2362978] [UniProtKB: P43351] | ||||||||
| ChEMBL | Inhibition of RAD52 (unknown origin) assessed as effect on RAD52-mediated annealing of complementary oligonucleotides using T-28 ssDNA substrate by FRET assay | B | 4.7 | pIC50 | 20000 | nM | IC50 | US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (null) |
| ChEMBL | Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-ssDNA interaction using Cy3-dT30-Cy5 ssDNA by FRET assay | B | 6.59 | pIC50 | 255 | nM | IC50 | US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (null) |
| ELAV-like protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105924] [UniProtKB: Q14576] | ||||||||
| ChEMBL | Inhibition of ELAV3 (unknown origin)-artificial ARE complex formation after 30 mins in the presence of biotin-labeled RNA probe by chemiluminescence nucleic acid detection method | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2017) 60: 8257-8267 [PMID:28587461] |
| Enoyl-[acyl-carrier-protein] reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4] | ||||||||
| ChEMBL | Inhibition of Escherichia coli ENR | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| Enoyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5] | ||||||||
| ChEMBL | Inhibition of Plasmodium falciparum ENR using NADH substrate | B | 6.54 | pKi | 291 | nM | Ki | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| ChEMBL | Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate | B | 6.99 | pKi | 102 | nM | Ki | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| ChEMBL | Inhibition of Plasmodium falciparum ENR in presence of triclosan | B | 7.8 | pKi | 16 | nM | Ki | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| ChEMBL | Inhibition of Plasmodium falciparum ENR | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| ChEMBL | Inhibition of FabI | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| Fatty acid synthase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7] | ||||||||
| ChEMBL | Inhibition of FabZ | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| Fatty acid synthase in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795136] [UniProtKB: P12276] | ||||||||
| ChEMBL | Inhibition of chicken liver FASN ketoreductase activity | B | 4.17 | pIC50 | 68000 | nM | IC50 | J Med Chem (2011) 54: 5615-5638 [PMID:21726077] |
| ChEMBL | Inhibition of chicken liver FASN after 3 hrs | B | 4.38 | pIC50 | 42000 | nM | IC50 | J Med Chem (2011) 54: 5615-5638 [PMID:21726077] |
| Genome polyprotein in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9] | ||||||||
| ChEMBL | Inhibition of Zika virus NS2B (1421 to 1469 residues) - NS3 (1503 to 1688 residues) expressed in Escherichia coli BL21(DE3) cells using Dabcyl-KTSAVLQSGFRKME-Edans as substrate after 11 mins by FRET assay | B | 4.05 | pIC50 | 89000 | nM | IC50 | J Med Chem (2020) 63: 470-489 [PMID:31549836] |
| Glucose-6-phosphate 1-dehydrogenase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075249] [UniProtKB: P11412] | ||||||||
| ChEMBL | Inhibition of yeast G6PD | B | 6.74 | pIC50 | 180 | nM | IC50 | Bioorg Med Chem (2008) 16: 3580-3586 [PMID:18313308] |
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Inhibition of MET kinase | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 6543-6545 [PMID:19839593] |
| Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
| ChEMBL | Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP | B | 6.12 | pIC50 | 760 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2763-2767 [PMID:11591519] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibition of p38alpha after 1 hr by ELISA | B | 5.83 | pIC50 | 1470 | nM | IC50 | J Nat Prod (2010) 73: 2035-2041 [PMID:21080642] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 | F | 4.4 | pIC50 | 40000 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 4.95 | pIC50 | 11300 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074] | ||||||||
| ChEMBL | Inhibition of chymotrypsin-like activity of purified human 20S proteasome assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 30 mins by fluorometric analysis | B | 6.71 | pIC50 | 194 | nM | IC50 | Eur J Med Chem (2019) 167: 291-311 [PMID:30776692] |
| SYNJ1/Synaptojanin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523136] [GtoPdb: 1461] [UniProtKB: O43426] | ||||||||
| ChEMBL | Inhibition of C-Myc/DDK-tagged human recombinant SYNJ1 expressed in HEK293T cells assessed as reduction in 5'-phosphatase activity incubated for 8 mins using fluorescently-labeled PI(3,4)P2 probe and Tapp1 PH-domain as detector protein by fluorescence polarization competitive assay | B | 4.8 | pIC50 | <=15900 | nM | IC50 | US-20170042857-A1. Synaptojanin-2 inhibitors for use in the treatment of cancer (null) |
| ChEMBL | Inhibition of C-Myc/DDK-tagged human recombinant SYNJ1 expressed in HEK293T cells assessed as reduction in 5'-phosphatase activity incubated for 8 mins using fluorescently-labeled PI(3,4)P2 probe and Tapp1 PH-domain as detector protein by fluorescence polarization competitive assay | B | 4.8 | pIC50 | <=15900 | nM | IC50 | WO-2015079413-A2. Synaptojanin-2 inhibitors and uses thereof (null) |
| SYNJ2/Synaptojanin-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523129] [GtoPdb: 1462] [UniProtKB: O15056] | ||||||||
| ChEMBL | Inhibition of C-Myc/DDK-tagged human recombinant SYNJ2 expressed in HEK293T cells assessed as reduction in 5'-phosphatase activity incubated for 8 mins using fluorescently-labeled PI(3,4)P2 probe and Tapp1 PH-domain as detector protein by fluorescence polarization competitive assay | B | 5.54 | pIC50 | 2880 | nM | IC50 | US-20170042857-A1. Synaptojanin-2 inhibitors for use in the treatment of cancer (null) |
| ChEMBL | Inhibition of C-Myc/DDK-tagged human recombinant SYNJ2 expressed in HEK293T cells assessed as reduction in 5'-phosphatase activity incubated for 8 mins using fluorescently-labeled PI(3,4)P2 probe and Tapp1 PH-domain as detector protein by fluorescence polarization competitive assay | B | 5.54 | pIC50 | 2880 | nM | IC50 | WO-2015079413-A2. Synaptojanin-2 inhibitors and uses thereof (null) |
| ChEMBL | Inhibition of recombinant full length C-Myc/DDK-tagged human SYNJ2 expressed in HEK293T cells using PI(3,4,5)P3 as substrate incubated for 8 mins assessed as hydrolysis of PI(3,4,5)P3 to PI(3,4)P2 by fluorescence polarization assay | B | 5.54 | pIC50 | 2880 | nM | IC50 | US-20170165285-A1. Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors (null) |
| TAS2R39 in Human [GtoPdb: 675] [UniProtKB: P59534] | ||||||||
| GtoPdb | - | - | 4.67 | pEC50 | 21300 | nM | EC50 | Biosci Biotechnol Biochem (2014) 78: 1753-6 [PMID:25273142] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
