L023103 [Ligand Id: 2194] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL445816
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  • V1A receptor/Vasopressin V1a receptor in Human [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
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  • V1B receptor/Vasopressin V1b receptor in Human [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901]
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  • V2 receptor/Vasopressin V2 receptor in Human [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559]
ChEMBL Displacement of [125I]OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells B 9.19 pKi 0.65 nM Ki J Med Chem (2005) 48: 7882-7905 [PMID:16302826]
ChEMBL Displacement of [3H]-oxytocin from human oxytocin receptor expressed in HEK293-EBNA cells B 9.19 pKi 0.65 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]
GtoPdb - - 9.2 pKi - - - J Med Chem (2005) 48: 7882-905 [PMID:16302826]
ChEMBL Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells F 7.85 pIC50 14 nM IC50 J Med Chem (2005) 48: 7882-7905 [PMID:16302826]
OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536]
ChEMBL Displacement of [125I]OVTA antagonist from rat oxytocin receptor expressed in HEK293-EBNA cells B 9.17 pKi 0.67 nM Ki J Med Chem (2005) 48: 7882-7905 [PMID:16302826]
ChEMBL Displacement of [3H]-oxytocin from rat oxytocin receptor expressed in HEK293-EBNA cells B 9.17 pKi 0.67 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]
GtoPdb - - 9.2 pKi - - - J Med Chem (2005) 48: 7882-905 [PMID:16302826]
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
ChEMBL Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells B 7.38 pKi 42 nM Ki J Med Chem (2005) 48: 7882-7905 [PMID:16302826]
GtoPdb - - 7.4 pKi - - - J Med Chem (2005) 48: 7882-905 [PMID:16302826]
ChEMBL Displacement of [3H]vasopressin from vasopressin V1a receptor in human liver tissue B 9.19 pKi 0.65 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]
V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901]
ChEMBL Displacement of [3H]vasopressin from human vasopressin V1b receptor expressed in CHO cells B 5.45 pKi 3539 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]
V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
ChEMBL Displacement of [3H]vasopressin from vasopressin V2 receptor in human kidney tissue B 9.17 pKi 0.67 nM Ki J Med Chem (2010) 53: 6525-6538 [PMID:20550119]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]