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ChEMBL ligand: CHEMBL445816 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
ChEMBL | Displacement of [125I]OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells | B | 9.19 | pKi | 0.65 | nM | Ki | J Med Chem (2005) 48: 7882-7905 [PMID:16302826] |
ChEMBL | Displacement of [3H]-oxytocin from human oxytocin receptor expressed in HEK293-EBNA cells | B | 9.19 | pKi | 0.65 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
GtoPdb | - | - | 9.2 | pKi | - | - | - | J Med Chem (2005) 48: 7882-905 [PMID:16302826] |
ChEMBL | Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells | F | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2005) 48: 7882-7905 [PMID:16302826] |
OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536] | ||||||||
ChEMBL | Displacement of [125I]OVTA antagonist from rat oxytocin receptor expressed in HEK293-EBNA cells | B | 9.17 | pKi | 0.67 | nM | Ki | J Med Chem (2005) 48: 7882-7905 [PMID:16302826] |
ChEMBL | Displacement of [3H]-oxytocin from rat oxytocin receptor expressed in HEK293-EBNA cells | B | 9.17 | pKi | 0.67 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
GtoPdb | - | - | 9.2 | pKi | - | - | - | J Med Chem (2005) 48: 7882-905 [PMID:16302826] |
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
ChEMBL | Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (2005) 48: 7882-7905 [PMID:16302826] |
GtoPdb | - | - | 7.4 | pKi | - | - | - | J Med Chem (2005) 48: 7882-905 [PMID:16302826] |
ChEMBL | Displacement of [3H]vasopressin from vasopressin V1a receptor in human liver tissue | B | 9.19 | pKi | 0.65 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901] | ||||||||
ChEMBL | Displacement of [3H]vasopressin from human vasopressin V1b receptor expressed in CHO cells | B | 5.45 | pKi | 3539 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
ChEMBL | Displacement of [3H]vasopressin from vasopressin V2 receptor in human kidney tissue | B | 9.17 | pKi | 0.67 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]