compound 36 [PMID: 34843241] [Ligand Id: 12713] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL4868242
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG by FLIPR TETRA method B 5 pIC50 >10000 nM IC50 J Med Chem (2021) 64: 17004-17030 [PMID:34843241]
Interleukin-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5880] [UniProtKB: P60568]
ChEMBL Inhibition of IL2 in thapsigargin stimulated human whole blood B 6.74 pIC50 182.8 nM IC50 J Med Chem (2021) 64: 17004-17030 [PMID:34843241]
ChEMBL Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs by ELISA B 7.96 pIC50 11 nM IC50 J Med Chem (2021) 64: 17004-17030 [PMID:34843241]
Orai1/ORAI1/STIM1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3832644] [GtoPdb: 2964] [UniProtKB: Q13586, Q96D31]
ChEMBL Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current by manual patch clamp based electrophysiological method B 7.12 pIC50 76 nM IC50 J Med Chem (2021) 64: 17004-17030 [PMID:34843241]
TNF-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1825] [UniProtKB: P01375]
ChEMBL Inhibition of TNF-alpha in thapsigargin stimulated human whole blood B 6.16 pIC50 694.5 nM IC50 J Med Chem (2021) 64: 17004-17030 [PMID:34843241]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]