Synonyms: C-118335 | C118335 | compound 7 [PMID: 23131342] | CORT118335
Compound class:
Synthetic organic
Comment: Miricorilant (CORT118335) is a potent, orally active non-steroidal glucocorticoid receptor (GR) antagonist that is being developed by Corcept Therapeutics [2]. Selective GR antagonists are being investigated for their potential to mitigate antipsychotic-induced weight gain, a beneficial activity that was first identified using the dual GR/progesterone receptor antagonist mifepristone [1].
Hunt et al. (2010) specify CORT118335 with the InChIKey GVVUZBSCYAVFTI-IYARVYRRSA-N and as the trans isomer (or the (1r,4r) isomer) [2], which corresponds to the chemical structure submitted to the WHO for the INN miricorilant. Note that PubChem lists this compound in the form without any specified stereochemistry, with PubChem CID 66550324, and that ChEMBL record the cis (or (1s,4s)) isomer as CHEMBL2204043 (InChIKey GVVUZBSCYAVFTI-HDICACEKNA-N). ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
6-(trans-4-phenylcyclohexyl)-5-{[3-(trifluoromethyl)phenyl]methyl}pyrimidine-2,4(1H,3H)-dione |
International Nonproprietary Names ![]() |
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INN number | INN |
10853 | miricorilant |
Synonyms ![]() |
C-118335 | C118335 | compound 7 [PMID: 23131342] | CORT118335 |
Database Links ![]() |
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GtoPdb PubChem SID | 375973247 |
PubChem CID | 66550324 |
Search Google for chemical match using the InChIKey | GVVUZBSCYAVFTI-IYARVYRRSA-N |
Search Google for chemicals with the same backbone | GVVUZBSCYAVFTI |
Search PubMed clinical trials | miricorilant |
Search PubMed titles | miricorilant |
Search PubMed titles/abstracts | miricorilant |
UniChem Compound Search for chemical match using the InChIKey | GVVUZBSCYAVFTI-IYARVYRRSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | GVVUZBSCYAVFTI-IYARVYRRSA-N |