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Synonyms: CGT-003 | CGT003 | E2F Duplex Decoy
Compound class:
Nucleic acid
Comment: Edifoligide is an oligonucleotide decoy that binds to and inhibits activity of E2F transcription factors that regulate expression of genes controlling smooth muscle cell proliferation. This is proposed as a mechanism to reduce the progressive neointimal hyperplasia that contributes to vein graft failure following coronary artery bypass graft (CABG) surgery [2-4].
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Classification  |
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| Compound class | Nucleic acid |
| Compound subclass | |
| Target | E2F transcription factors |
| International Nonproprietary Names |
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| INN number | INN |
| 8323 | edifoligide |
| Synonyms |
| CGT-003 | CGT003 | E2F Duplex Decoy |
| Database Links |
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| CAS Registry No. | 328538-04-1 (source: WHO INN record) |
| ChEMBL Ligand | CHEMBL2109058 |
| DrugBank Ligand | DB06556 |
| GtoPdb PubChem SID | 504705452 |
| Search PubMed clinical trials | edifoligide |
| Search PubMed titles | edifoligide |
| Search PubMed titles/abstracts | edifoligide |
