ChEMBL ligand: CHEMBL2316582 (D-824, D-824 DIMESYLATE, GZD-824, Gzd-824 dimesylate, GZD-824 DIMESYLATE, Hqp1351, HQP-1351, HQP1351, HQP-1351 DIMESYLATE, HQP1351 DIMESYLATE, Olverembatinib, Olverembatinib dimesylate)
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Binding affinity to phosphorylated ABL1 T315I mutant (unknown origin) after 1 hr	B	8.49	pKd	3.2	nM	Kd	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Binding affinity to non phosphorylated ABL1 F317I mutant (unknown origin) after 1 hr	B	8.74	pKd	1.8	nM	Kd	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Binding affinity to non phosphorylated ABL1 T315I mutant (unknown origin) after 1 hr	B	9.15	pKd	0.71	nM	Kd	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Binding affinity to non phosphorylated ABL1 Q252H mutant (unknown origin) after 1 hr	B	9.34	pKd	0.46	nM	Kd	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Binding affinity to phosphorylated wild type ABL1 (unknown origin) after 1 hr	B	9.47	pKd	0.34	nM	Kd	J Med Chem (2013) 56: 879-894 [PMID:23301703]
GtoPdb	Binding affinity for nonphosphorylated Abl1 as determined using an active-site-dependent competitive binding assay (KINOMEscan).	-	9.49	pKd	0.32	nM	Kd	J Med Chem (2013) 56: 879-94 [PMID:23301703]
ChEMBL	Binding affinity to non phosphorylated wild type ABL1 (unknown origin) after 1 hr	B	9.49	pKd	0.32	nM	Kd	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Binding affinity to phosphorylated ABL1 E255K mutant (unknown origin) after 1 hr	B	9.55	pKd	0.28	nM	Kd	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Binding affinity to phosphorylated ABL1 M351T mutant (unknown origin) after 1 hr	B	9.64	pKd	0.23	nM	Kd	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Binding affinity to non phosphorylated ABL1 H396P mutant (unknown origin) after 1 hr	B	9.74	pKd	0.18	nM	Kd	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Inhibition of human recombinant ABL1 G250E mutant expressed in insect cells after 30 mins by FRET assay	B	9.15	pIC50	0.71	nM	IC50	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Inhibition of human recombinant ABL1 T315I mutant expressed in insect cells after 30 mins by FRET assay	B	9.17	pIC50	0.68	nM	IC50	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Inhibition of human recombinant ABL1 Y253F mutant expressed in insect cells after 30 mins by FRET assay	B	9.46	pIC50	0.35	nM	IC50	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Inhibition of human recombinant ABL1 H396P mutant expressed in insect cells after 30 mins by FRET assay	B	9.46	pIC50	0.35	nM	IC50	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Inhibition of human recombinant wild type ABL1 expressed in insect cells after 30 mins by FRET assay	B	9.47	pIC50	0.34	nM	IC50	J Med Chem (2013) 56: 879-894 [PMID:23301703]
GtoPdb	Inhibition of wild type Abl1 kinase activity was determined using the proprietary FRET-based Z′-Lyte assay.	-	9.47	pIC50	0.34	nM	IC50	J Med Chem (2013) 56: 879-94 [PMID:23301703]
ChEMBL	Inhibition of human recombinant ABL1 M351T mutant expressed in insect cells after 30 mins by FRET assay	B	9.54	pIC50	0.29	nM	IC50	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Inhibition of human recombinant ABL1 E255K mutant expressed in insect cells after 30 mins by FRET assay	B	9.57	pIC50	0.27	nM	IC50	J Med Chem (2013) 56: 879-894 [PMID:23301703]
ChEMBL	Inhibition of human recombinant ABL1 Q252H mutant expressed in insect cells after 30 mins by FRET assay	B	9.82	pIC50	0.15	nM	IC50	J Med Chem (2013) 56: 879-894 [PMID:23301703]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]